A Study on the Infiltrate Risk of pulmonary Ground-Glass Opacities Based on Thin-Section CT Scans of the Chest
10.11969/j.issn.1673-548X.2025.05.010
- VernacularTitle:基于胸部CT薄层扫描的肺磨玻璃病变浸润性风险值的研究
- Author:
Lei SU
1
;
Yan GAO
;
Bing WEI
Author Information
1. 100053 北京,首都医科大学宣武医院胸外科
- Publication Type:Journal Article
- Keywords:
Ground glass opacity;
Comprehensive imaging features;
Risk value;
Infiltrative lesion
- From:
Journal of Medical Research
2025;54(5):45-51
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the risk value of comprehensive imaging features of lung ground glass opacity(GGO)based on thin-section CT(TSCT),and to provide a reference for clinical doctors in predicting the risk of GGO invasion.Methods A retrospec-tive analysis was conducted on the clinical data of 3224 patients with pulmonary GGO lesions who underwent video-assisted thoracoscopic surgery at Xuanwu Hospital of Capital Medical University from January 2020 to December 2023.The risk value of GGO comprehensive im-aging features was the sum of the dynamic features of a single imaging feature,including morphological and size,margin features,internal features,type features,CTR features,observation time and results.Results Out of 3224 patients,987(30.6％)were male and 2237(69.4％)were female.The average maximum diameter of GGO was 13.38±7.80mm.The average observation time was 13.49±21.07 months.91.1％(2936 cases)of postoperative pathological reports were malignant lesions,of which,37.5％(1102 cases)were preinva-sive lesions,and 62.5％(1834 cases)were infiltrative lesions.The results of multiple Logistic regression analysis show that the diame-ter,pleural sign,bronchiolar sign,vascular sign,GGO type,CTR feature and risk value of GGO were independent influencing factors for predicting it as an infiltrative lesion.However,the ROC analysis results showed that compared with the single imaging feature of GGO,the area under the curve of the risk value(AUC=0.897,95％ CI:0.886-0.909),cut-off value was 25.5,with sensitivity 82.6％and specificity of 81.4％,had higher diagnostic value for evaluating GGO as infiltrative lesions.Conclusion The risk value of compre-hensive features of GGO based on TSCT would help clinical doctors to make more accurate predictions about the infiltration risk of GGO.
