Study on the Correlation between Asprosin,Angiopoietin-like Protein 3 and Peripheral Vascular Disease in Type 2 Diabetes Mellitus
10.11969/j.issn.1673-548X.2025.05.014
- VernacularTitle:血清白脂素、血管生成素样蛋白3与2型糖尿病并发周围血管病变的相关性研究
- Author:
Mengqi YIN
1
;
Chun WANG
1
;
Yinchen YU
1
Author Information
1. 233000 蚌埠医科大学第二附属医院
- Publication Type:Journal Article
- Keywords:
Diabetic peripheral vascular disease;
Asprosin;
Angiopoietin-like protein 3
- From:
Journal of Medical Research
2025;54(5):73-77
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between asprosin(Asp)and angiopoietin-like protein 3(ANGPTL3)levels and Diabetic Peripheral Vascular diseases in type 2diabetes mellitus Disease,DPVD)to evaluate their predictive value for DPVD.Methods A total of 141 patients with type 2diabetes who met the inclusion criteria were included and divided into non-DPVD group(n=71)and DPVD group(n=70),and healthy subjects in the same period were selected as normal control group(n=37).General data and expression levels of Asp and ANGPTL3 in the three groups were compared.Spearman correlation analysis was used to explore the correlation between Asp and ANGPTL3 levels and clinical indicators,and Logistic regression was used to analyze the influencing factors of DPVD.The predictive value of serum Asp and ANGPTL3 levels to DPVD was analyzed by receiver operating characteristic curve(ROC).Results Compared with non-DPVD group,the levels of asprosin and angiopoietin-like protein 3 in DPVD group were higher(all P＜0.05).Spearman correlation analysis showed that Asp level was positively correlated with age,SBP,FBG,LDL-C and ANGPTL3(all P＜0.05).ANGPTL3 level was positively correlated with age,SBP,DBP,FBG,TC,TG,LDL-C and Asp(all P＜0.05).Age,course of disease,HbA1c,TG,LDL-C,FCP,Asp and ANGPTL3 were the influencing factors of DPVD(all P＜0.05),while course of disease,TG,Asp and ANGPTL3 were the independent influencing factors of DPVD(all P＜0.05).ROC curve results showed that Asp and ANGPTL3 levels alone predicted DPVD AUC of 0.679 and 0.706,corresponding sensitivity of 88.7％and 78.9％,specificity of 47.1％and 55.7％,respectively.The combined prediction of Asp and ANGPTL3 levels for DPVD was 0.777 AUC,80.3％sensitivity and 64.3％specificity.Conclusion Asp and ANGPTL3have certain predictive value for DPVD,and their combined predictive value is higher.
