Exploring the Correlation between TG/HDL-C and Cerebral Infarction in 45-60 Year Olds
10.11969/j.issn.1673-548X.2025.05.006
- VernacularTitle:探讨45～60岁人群TG/HDL-C与脑梗死的相关性
- Author:
Ye WANG
1
;
Shiwen ZHANG
1
;
Xin ZOU
1
Author Information
1. 300381 天津中医药大学第一附属医院针灸研究所、国家中医针灸临床医学研究中心
- Publication Type:Journal Article
- Keywords:
Cerebral infarction;
T2DM;
TG/HDL-C;
Insulin resistance;
Middle-aged women
- From:
Journal of Medical Research
2025;54(5):23-28
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between triglyceride(TG)and high-density lipoprotein cholesterol(HDL-C)ratios and cerebral infarct(CI)in people aged 45-60 years,and to analyze the difference of this correlation between genders.Methods In this study,patients were divided into CI without type 2diabetes(T2DM)group(CI-NG group,HbA1c＜5.9％)and CI with T2DM group(CI-T2DM group,HbA1c ≥6.5％),and TG/HDL-C was divided into tertiles(T1＜1.08,1.08≤T2＜1.72,T3≥1.72),and the relationship between TG/HDL-C and CI was analyzed by binary Logistic regression using T1 as a reference,and strati-fied according to sex for discussion.Results Among 1495subjects,423(28.29％)patients were in the CI-T2DM group.Binary Logis-tic regression showed a significant correlation between TG/HDL-C and CI-T2DM patients(P＜0.001),and this correlation was 1.207 times higher than that of CI-NG patients(OR=1.207).Correction for confounders revealed that this correlation was enhanced(OR=1.317),with the highest tertile of TG/HDL-C correlating 3.277 times more than that of CI-T2DM patients(OR=3.277).Stratifica-tion according to gender showed that TG/HDL-C was significantly correlated with CI-T2DM patients of different genders(P＜0.001),but more significantly in female patients(OR=2.000)than in male patients(OR=1.224).The highest tertile of TG/HDL-C in women was 5.598 times more correlated with CI-T2DM patients than the lowest tertile(OR=5.598).Conclusion In people aged 45 to 60 years,the correlation between TG/HDL-C and CI-T2DM patients was more significant compared with CI-NG patients and was positively correlated and was more pronounced in female patients.
