Research hotspots and trends in application of tissue engineering in peripheral nerve injury
- VernacularTitle:周围神经损伤领域组织工程技术应用的研究热点与趋势变化
- Author:
Xiaoxuan ZHAO
1
;
Shuaiyi LIU
;
Zheng XING
;
Qingwen LI
;
Xiaolei CHU
;
Qi LI
Author Information
- Publication Type:Journal Article
- Keywords: peripheral nerve injury; visual analysis; tissue engineering; nerve conduit; nerve scaffold; Schwann cell; stem cell; 3D printing technology; engineered tissue construction
- From: Chinese Journal of Tissue Engineering Research 2025;29(30):6591-6600
- CountryChina
- Language:Chinese
- Abstract: BACKGROUND:Peripheral nerve injuries can cause severe functional disabilities in patients,and long-segment nerve defects often fail to regenerate spontaneously.In recent years,tissue engineering techniques have gradually been applied to the repair of long-segment nerve injuries,yet research hotspots and development trends are unclear.OBJECTIVE:To analyze the research hotspots and trends in the field of peripheral nerve tissue engineering over the past 20 years using bibliometric software.METHODS:CiteSpace 6.2R6 software was employed to conduct highly cited analysis and keyword analysis on peripheral nerve tissue engineering literature published from 2004 to 2024 in the Web of Science and China National Knowledge Infrastructure(CNKI)databases.The keyword analysis encompasses keyword co-occurrence analysis,keyword clustering analysis,keyword timeline analysis,and keyword emergence analysis.RESULTS AND CONCLUSION:A total of 2 961 articles from the Web of Science database and 1171 articles from the CNKI database were included.The number of publications in the Web of Science database showed fluctuations but exhibited an overall increasing trend year by year,while the publication volume in the CNKI database remained relatively stable annually.Most of the top ten most cited articles in the Web of Science database were review articles.The results of the keyword analysis from Web of Science and CNKI databases indicated that the most studied nerve tissue engineering materials over the past 20 years include silk fibroin,collagen,chitosan,polycaprolactone,polylactic acid,and graphene.The biochemical cues investigated in these materials include olfactory ensheathing cells,Schwann cells,stem cells,and nerve growth factors.The most commonly employed external physical factor is electrical stimulation applied to the materials.Among various tissue engineering techniques,electrospinning technology and 3D printing technology have been the most extensively researched.
