Analysis of the efficacy of modified electroconvulsive therapy in schizophrenia patients across different genders
10.3969/j.issn.1002-0152.2025.02.004
- VernacularTitle:无抽搐电休克对精神分裂症疗效的性别差异分析
- Author:
Jiajun REN
1
;
Yuting LI
;
Tingting WANG
;
Shuangshuang FENG
;
Hongcheng XIE
;
Junfan LIANG
;
Hongli ZHANG
;
Ziyuan LIN
;
Bo XIANG
;
Kezhi LIU
;
Xuemei LIANG
Author Information
1. 西南医科大学附属医院心身医学科(泸州 646000);西南医科大学
- Publication Type:Journal Article
- Keywords:
Schizophrenia;
Modified electroconvulsive therapy;
Gender differences;
Adverse reaction;
PANSS;
Correlation analysis;
Curative effect;
Influencing factors
- From:
Chinese Journal of Nervous and Mental Diseases
2025;51(2):89-94
- CountryChina
- Language:Chinese
-
Abstract:
Objective To Investigate the efficacy of modified electroconvulsive therapy(MECT)in patients with schizophrenia across different genders.Methods From May 2018 to August 2022,481 patients with schizophrenia were recruited from three psychiatric hospitals in Luzhou,Zigong,and Yibin.According to gender grouping,both groups received adjunctive MECT treatment for two consecutive weeks for a total of six treatments.The differences in positive and negative syndrome scale(PANSS)scores before and after treatment,UKU adverse reaction rating scale(UKU),and gastrointestinal symptom rating scale(GSRS)scores were compared between the two groups.Results After quality control,463 cases were followed up for analysis including 246 males and 217 females.Compared with pre-treatment,the total PANSS score and scores on each subscale were significantly reduced in both genders after treatment(P<0.001).When comparing the reduction rates between the groups,the male patients showed a higher reduction rate in negative symptoms than the female patients(31.24%±30.24%vs.25.80%±33.96%,P<0.05).However,there were no significant differences between the two groups in the reduction rates of the total score,positive symptoms,and general psychopathology(P>0.05).The comparison of adverse reactions showed that the frequency of other types of adverse reactions was higher in female patients than in male patients(47.47%vs.37.80%,P<0.05).However,no significant differences were observed in the adverse reactions related to the mental,neurological,autonomic nervous system,and gastrointestinal systems(P>0.05).Correlation analysis revealed that the reduction rate of the PANSS total score was positively correlated with smoking history(r=0.135,P=0.034)and alcohol history(r=0.160,P=0.012)in male patients,while the reduction rate of the PANSS total score was negatively correlated with the disease duration(r=-0.210,P=0.002)and positively correlated with the age of onset(r=0.145,P=0.032)in female patients.Conclusion MECT is significantly effective for both male and female patients with schizophrenia.Compared to female patients,MECT shows a more pronounced effect on negative symptoms in male patients.Additionally,the factors related to the efficacy of MECT differ between genders,indicating that it is necessary to consider the clinical characteristics of patients comprehensively when selecting an MECT treatment plan.
