Meta-analysis of transcranial direct current stimulation in improving lower limb motor dysfunction in stroke patients
- VernacularTitle:经颅直流电刺激改善脑卒中患者下肢运动功能障碍的Meta分析
- Author:
He WANG
1
;
Shaohong YU
Author Information
- Publication Type:Journal Article
- Keywords: stroke; balance; walking; lower limb; motor; dysfunction; transcranial direct current stimulation; meta-analysis
- From: Chinese Journal of Tissue Engineering Research 2025;29(30):6556-6565
- CountryChina
- Language:Chinese
- Abstract: OBJECTIVE:To systematically evaluate the effects of transcranial direct current stimulation on lower limb motor function in patients with stroke.METHODS:The randomized controlled trials about the effects of transcranial direct current stimulation on patients with stroke were retrieved from databases(PubMed,Web of Science,Embase,Cochrane Library,Scopus,CNKI,VIP,and WanFang Data)from the establishment of the databases to September 22,2024.RevMan 5.4 software and Stata 14.0 software were used for traditional meta-analysis and network meta-analysis,respectively.GRADE was used to evaluate the level of evidence.RESULTS:A total of 17 studies involving 851 patients were included.Traditional meta-analysis showed that transcranial direct current stimulation improved the Fugl-Meyer Lower Extremity Motor Function Scale scores[MD=1.97,95％CI(0.78,3.16),P＜0.01],Berg Balance Scale scores[MD=3.92,95％CI(1.67,6.17),P＜0.01],and Tinetti Balance and Gait Scale score[MD=2.62,95％CI(0.44,4.80),P＜0.05],and reduced the Timed Up-and-Go Test time[MD=-1.82,95％CI(-2.51,-1.12),P＜0.01]and Five Times Sit-To-Stand test time[MD=-0.78,95％CI(-1.31,-0.26),P＜0.01].Network meta-analysis showed that transcranial direct current stimulation was more effective in the treatment of lower limb motor function in stroke patients aged 50-60 years with a disease duration of ≤ 6 months,and that a treatment regimen with a current intensity of 2 mA,a treatment duration of＞30 minutes per day,and a period of intervention of＞3 weeks was more effective in the improvement of lower limb motor ability in stroke patients.CONCLUSION:Current evidence suggests that transcranial direct current stimulation has a better therapeutic effect on lower limb motor function,walking ability,and balance in patients with stroke,in which the improvement of lower limb motor function is affected by the patient's age and duration of the disease,and there is a dose-response relationship between the current intensity,the duration of the daily treatment time,and the cycle of the intervention to a certain extent.
