A case of acute kidney injury due to suspected omadacycline
10.12173/j.issn.1005-0698.202412137
- VernacularTitle:疑似奥马环素致急性肾损伤1例
- Author:
Huan LIN
1
;
Xiuheng YU
;
Xiaobin HUANG
;
Yu ZHAO
Author Information
1. 重庆医科大学药学院(重庆 400016);重庆医科大学附属大学城医院药学部(重庆 401331)
- Publication Type:Journal Article
- Keywords:
Omadacycline;
Acute kidney injury;
Adverse drug reaction;
Case report
- From:
Chinese Journal of Pharmacoepidemiology
2025;34(3):353-358
- CountryChina
- Language:Chinese
-
Abstract:
An 81-year-old female patient was treated with anti-infective therapy of omadacycline for a soft-tissue skin infection,and developed acute kidney injury(AKI)6 d after the administration of omadacycline.Laboratory tests showed that the urea was 6.11 mmol·L-1,the creatinine was 236.40 μmol·L-1,and the glomerular filtration rate was 18.18 mL·min-1·(1.73m2)-1,which led to the definitive diagnosis of AKI.The association score of the suspected drug using Naranjo's Assessment Scale suggests that the patient's adverse reaction of AKI was suspected to be caused by omadacycline.After stopping omadacycline,the patient's renal function indicators gradually recovered after symptomatic treatment with renal protection and continuous blood purification.This paper discussed the occurrence mechanism and treatment prognosis of AKI caused by omadacycline.It suggestd that clinical use of omadacycline should be alert to the adverse effects of renal injury,and timely medication analysis and symptomatic treatment should be carried out to ensure the safety and effectiveness of treatment.
