Clinical Characteristics of Autoimmune Gastritis Patients Complicated With Colorectal Polyps
10.3969/j.issn.1008-7125.2024.07.002
- VernacularTitle:自身免疫性胃炎合并结直肠息肉患者的临床特征分析
- Author:
Jingzheng JIN
1
;
Xiao LIANG
1
;
Zhao LI
1
;
Yiming SONG
1
;
Xiaobo LI
1
Author Information
1. 上海交通大学医学院附属仁济医院消化内科 上海市消化疾病研究所(200001)
- Publication Type:Journal Article
- Keywords:
Autoimmune Gastritis;
Colorectal Polyps;
Gastric Polyps;
Gastrin-17
- From:
Chinese Journal of Gastroenterology
2024;29(7):391-395
- CountryChina
- Language:Chinese
-
Abstract:
Background:The association between atrophic gastritis and colorectal polyps has been reported.Autoimmune gastritis(AIG)leads to parietal cell destruction,reduced gastric acid secretion and gastric mucosal atrophy,which may increase the risk of colorectal polyps.However,there are few studies on AIG and colorectal polyps.Aims:To analyze the clinical characteristics of AIG patients complicated with colorectal polyps.Methods:AIG patients complicated with colorectal polyps admitted to Renji Hospital,School of Medicine,Shanghai Jiao Tong University from June 2019 to July 2023 were retrospectively recruited.The medical history was reviewed,data on age at diagnosis,gender,anemia,anti-parietal cell antibody(PCA),anti-intrinsic factor antibody(IFA),pepsinogens(PGs),gastrin-17,vitamin B12,and the presence and pathological features of polyps were collected and analyzed.Results:Seventy-seven cases of AIG patients complicated with colorectal polyps,predominantly females(66.2%),were enrolled.The median age at diagnosis was 63 years old.The positivity rate for PCA was 84.4%.The most common pathological type of colorectal polyps was adenomatous polyps(46.3%),followed by hyperplastic polyps(29.9%).The most common location of colorectal polyps was sigmoid colon(29.9%),followed by transverse colon(20.9%)and ascending colon(19.4%).Thirty-three patients(42.9%)also complicated with gastric polyps,mainly the hyperplastic polyps located at corpus and fundus.Patients with gastric polyps presented higher positivity rate for PCA and higher serum PGⅡand gastrin-17 levels as compared with those without gastric polyps(all P<0.05).Conclusions:The most common pathological types of colorectal polyps in AIG patients are adenomatous and hyperplastic polyps,and the most common sites are sigmoid colon,transverse colon and ascending colon.Nearly 40%of the patients complicated with gastric polyps simultaneously,which suggests that gastric polyps and colorectal polyps might have a symbiotic relationship under the background of gastric mucosal atrophy in AIG patients.
