Research Progress on Intratumoral Microorganisms in Digestive System Tumors
10.3969/j.issn.1008-7125.2024.07.008
- VernacularTitle:消化系统肿瘤内微生物的研究进展
- Author:
Yirong YANG
1
;
Yang LI
;
Limei GU
;
Xiaolong ZHANG
;
Tingsheng LING
Author Information
1. 南京中医药大学(210023)
- Publication Type:Journal Article
- Keywords:
Intratumoral Microorganisms;
Digestive System Neoplasms;
Intestinal Flora;
Tumor Microenvironment;
Therapy
- From:
Chinese Journal of Gastroenterology
2024;29(7):425-432
- CountryChina
- Language:Chinese
-
Abstract:
Digestive system tumors,such as esophageal cancer,gastric cancer,colorectal cancer,liver cancer,and pancreatic cancer,represent a yearly increase in their incidence and mortality rates,causing tremendous social economic burdens.Therefore,it is vital to elucidate the mechanisms of tumorigenesis and development of digestive system tumors and take corresponding intervention measures.The intratumoral microbiome forms an integral part of the tumor microenvironment.Recent studies have found that the intratumoral microbiome can regulate the biological behavior of tumors in multiple ways,including promoting DNA damage and mutations,facilitating tumor cell proliferation and metastasis,and influencing the tumor immune microenvironment.It is likely one of the key mechanisms in the development of digestive system tumors.This article reviewed the research progress on intratumoral microorganisms in digestive system tumors.
