Vascular Endothelial Growth Factor and D-Dimer Levels for Early Diagnosis of Ischemic Colitis
10.3969/j.issn.1008-7125.2024.07.005
- VernacularTitle:血管内皮生长因子和D-二聚体水平在缺血性结肠炎早期诊断中的价值
- Author:
Chong LU
1
;
Yuan CHEN
1
;
Minli HU
1
;
Jiaojiao WEI
1
;
Jin DING
1
;
Qunying WANG
1
Author Information
1. 浙江大学医学院附属金华医院消化内科(321000)
- Publication Type:Journal Article
- Keywords:
Colitis,Ischemic;
Vascular Endothelial Growth Factor;
D-Dimer;
Diagnosis
- From:
Chinese Journal of Gastroenterology
2024;29(7):409-413
- CountryChina
- Language:Chinese
-
Abstract:
Background:Ischemic colitis is a gastrointestinal emergency caused by intestinal wall ischemia,and in severe cases,it can even be life-threatening.Currently,there is a lack of reliable detection methods for ischemic colitis.Clinically,there is an urgent need for a specific detection method to improve the early diagnosis rate of ischemic colitis.Aims:To explore the values of serum vascular endothelial growth factor(VEGF)and plasma D-dimer levels for early diagnosis of ischemic colitis.Methods:A total of 40 patients with ischemic colitis admitted from June 2021 to June 2023 at the Affiliated Jinhua Hospital,Zhejiang University School of Medicine were served as the experimental group.Meanwhile,51 patients with acute enteritis were served as controls.The clinical manifestations,as well as the laboratory,radiological,and endoscopic results were compared between the two groups.A binary Logistic regression model was employed to analyze the risk factors for the onset of ischemic colitis.ROC curve was used to assess the diagnostic performance of serum VEGF and plasma D-dimer levels for the early diagnosis of ischemic colitis.Results:Compared with the control group,the proportion of patients with abdominal pain accompanied by hematochezia,and the serum VEGF and plasma D-dimer levels in the experimental group were significantly increased(all P<0.05).The results of binary Logistic regression model indicated that serum VEGF and plasma D-dimer levels were the risk factors for onset of ischemic colitis(all P<0.05).ROC curve analysis showed that the area under the curve(AUC)of serum VEGF and plasma D-dimer for diagnosing ischemic colitis were 0.93 and 0.88,respectively.The combination of these two indicators could further increase the diagnostic specificity and the AUC.Conclusions:Serum VEGF and plasma D-dimer levels can be served as early diagnostic markers for ischemic colitis.The combination of these two indicators can greatly improve the early diagnostic performance.
