Proportions and clinical significance of myeloid-derived suppressor cell subsets in the peripheral blood of ovarian cancer pa-tients
10.13602/j.cnki.jcls.2025.03.04
- VernacularTitle:卵巢癌患者外周血髓源性抑制细胞亚群比例及其临床意义
- Author:
Yepeng MAO
1
;
Ting WANG
;
Zhenzhen CAI
;
Zhijie LIU
;
Yuelu ZHANG
;
Ziqi TAO
;
Lingfei ZHOU
;
Lina YAN
;
Fang WANG
Author Information
1. 南京医科大学第一附属医院检验学部,南京 210029;南京医科大学第一附属医院国家医学检验临床医学研究中心分中心,南京 210029
- Publication Type:Journal Article
- Keywords:
ovarian cancer;
myeloid-derived suppressor cell;
lectin-like oxidized low-density lipoprotein receptor-1
- From:
Chinese Journal of Clinical Laboratory Science
2025;43(3):179-184
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the proportions of myeloid-derived suppressor cells(MDSCs)and their subsets,including poly-morphonuclear MDSCs(PMN-MDSCs),early-stage MDSCs(e-MDSCs),monocytic MDSCs(M-MDSCs),and lectin-like oxidized low-density lipoprotein receptor-1(LOX-1)positive PMN-MDSCs,in the peripheral blood of ovarian cancer(OC)patients and ana-lyze their correlations with clinicopathological parameters of the patients.Methods The proportions of MDSCs and their subsets in the peripheral blood of 38 OC patients(OC group)and 46 healthy individuals(healthy control group)were detected by flow cytometry.The levels of serum IL-10 and TGF-β were detected using ELISA.The OC group was further divided into LOX-1 high and low expres-sion subgroups based on the median proportion of LOX-1+PMN-MDSCs in MDSCs.Results The proportions of MDSCs,PMN-MDSCs,and LOX-1+PMN-MDSCs in the peripheral blood mononuclear cells(PBMCs)of the OC group were significantly higher than those in the healthy control group(U=492,P＜0.001;t=8.741,P＜0.000 1;U=223,P＜0.000 1).The proportions of M-MDSCs and e-MDSCs in the OC group were significantly lower than those in the healthy control group(t=4.366,P＜0.000 1;t=6.927,P＜0.000 1).The proportion of LOX-1+PMN-MDSCs in the lymph node metastasis group of OC patients was significantly higher than that in the non-metastasis group(t=2.249,P＜0.05).The levels of serum IL-10 and TGF-β in the OC group were significantly higher than those in the healthy control group(P＜0.05).In addition,the level of serum TGF-β in the LOX-1 high expression group was significantly higher than that in the LOX-1 low expression group(t=2.302,P＜0.05).Conclusion The proportion of LOX-1+PMN-MDSCs in the peripheral blood of OC patients is significantly increased and closely related to lymph node metastasis.
