Analysis of ToRCH infection status in female infertile women in Hangzhou region from 2021 to 2023
10.13602/j.cnki.jcls.2025.06.14
- VernacularTitle:杭州地区2021-2023年女性不孕症患者ToRCH感染情况分析
- Author:
Guoyu YIN
1
;
Yuan QIU
1
Author Information
1. 杭州市妇产科医院检验科,杭州 310000
- Publication Type:Journal Article
- Keywords:
ToRCH;
female infertility;
primary infertility;
secondary infertility
- From:
Chinese Journal of Clinical Laboratory Science
2025;43(6):461-465
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the ToRCH infection status in the female infertility patients in Hangzhou region.Methods A to-tal of 1 360 female infertility patients(687 with primary infertility and 673 with secondary infertility)who visited the Reproductive Medicine Center of Hangzhou Women's Hospital from January 2021 to December 2023,and 1 024 healthy early pregnancy controls were enrolled.The serum ToRCH-IgM and IgG antibodies were detected using chemiluminescence immunoassay.Results The overall ToRCH-IgM positive rate in female infertility patients was 5.15％.The ToRCH-IgM positive rates in the primary infertility,secondary infertility,and early pregnancy control groups were 4.37％,5.94％,and 3.52％,respectively.Notably the secondary infertility group had a significantly higher positive rate than the early pregnancy control group(P＜0.05).Among IgM antibodies against ToRCH patho-gens,the secondary infertility group had a higher positive rate of Herpes simplex virus types Ⅰ/Ⅱ(HSVⅠ/Ⅱ)IgM than the early preg-nancy control group(P＜0.05).For IgG antibodies,the infertility group showed significantly higher positive rates of Toxoplasma gondii(Tox),Rubella virus(RV),Cytomegalovirus(CMV),and HSVⅠ/Ⅱ IgG compared to the early pregnancy control group(P＜0.05).Age-stratified analysis revealed no statistical differences in IgM positive rates between infertility and control groups in either age group.In the younger group,the primary infertility subgroup had a higher Tox-IgG positive rate,while the secondary infertility subgroup showed higher positive rates for RV,CMV,HSVⅠ,HSVⅡ IgG compared to the control group.In the older group,CMV and HSVⅡ IgG positive rates in the secondary infertility subgroup had significantly higher CMV and HSVⅡ IgG positive rates than the control(P＜0.05).Among different seasons,only HSVⅠ-IgM positive rate in the secondary infertility group was significantly higher in summer(P＜0.05).Regarding the ToRCH-IgM/IgG infection pattern,mixed infections were more common in the secondary infertility group(P＜0.05).Conclusion Current infections are mainly HSVⅡ-IgM,while previous infections are mainly CMV-IgG and HSVⅠ-IgG.Screen-ing and monitoring of ToRCH infections should be strengthened in the infertility population for early prevention and treatment.
