Clinicopathological significance of USP9X and PD-L1 expression in pulmonary sarcomatoid carcinoma
10.13315/j.cnki.cjcep.2025.06.008
- VernacularTitle:肺肉瘤样癌中USP9X和PD-L1表达的临床病理意义
- Author:
Yang YANG
1
;
Qian LIU
1
;
Yi RU
1
;
Shasha ZHANG
1
;
Biao LIU
1
Author Information
1. 南京医科大学附属苏州医院病理科,苏州 215002
- Publication Type:Journal Article
- Keywords:
lung neoplasms;
sarcomatoid carcinoma;
USP9X;
PD-L1;
immunohistochemistry
- From:
Chinese Journal of Clinical and Experimental Pathology
2025;41(6):746-750
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To investigate the expression of ubiquitin-specific protease 9X(USP9X)and programmed cell death ligand 1(PD-L1)in pulmonary sarcomatoid carcinoma(PSC),and to assess their clinicopathological signif-icance.Methods Immunohistochemical staining was performed on 48 PSC specimens using the EnVision two-step method to detect USP9X and PD-L1 expression.The relationships between their expressions levels and clinicopathologi-cal parameters were analyzed.Results USP9X was positively expressed in 81.3％(39/48)of PSC cases,and the USP9X positivity rate was significantly higher in lymph node-negative tumors compared with lymph node-positive tumors(P＜0.05).PD-L1 expression was observed in 70.8％(34/48)of cases,with a significantly higher positivity rate in male patients than in female patients(P＜0.01).Correlation analysis showed a significant positive association between USP9X and PD-L1 expression in PSC(P＜0.05).Conclusion Both USP9X and PD-L1 are highly expressed in PSC,and their expression levels are significantly positively correlated.Combined detection of USP9X and PD-L1 may aid in predicting the efficacy of immunotherapy in PSC.
