Analysis of clinicopathological parameters and risk factors for the patients with connective tissue disease-associated interstitial lung disease complicated with EBV viraemia
10.13602/j.cnki.jcls.2025.03.03
- VernacularTitle:结缔组织病相关间质性肺疾病合并EB病毒血症患者临床病理参数及危险因素分析
- Author:
Hanyi JIANG
1
;
Tingting ZHAO
;
Yonglong XIAO
;
Jian HE
;
Rongfeng QI
;
Jin XU
;
Yin LIU
Author Information
1. 南京大学医学院附属鼓楼医院 呼吸与危重症医学,南京 210008
- Publication Type:Journal Article
- Keywords:
Epstein-Barr virus;
connective tissue disease;
interstitial lung disease;
clinicopathological parameter;
risk factor
- From:
Chinese Journal of Clinical Laboratory Science
2025;43(3):174-178
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinicopathological parameters and risk factors of the patients with connective tissue disease-associated interstitial lung disease(CTD-ILD)complicated with Epstein-Barr virus(EBV)viraemia.Methods The CTD-ILD pa-tients admitted to Department of Respiratory and Critical Care Medicine,Nanjing Drum Tower Hospital from January 2023 to April 2024 were collected.Based on the detection results of EBV DNA,the patients were divided into the EBV DNA(+)group and EBV DNA(-)group.The clinicopathological parameters of the two groups were analyzed.Results Out of 162 CTD-ILD patients who underwent EBV DNA testing,a total of 28 were found to have EBV viraemia.The levels of serum albumin([32.7±4.1]g/L vs[34.8±3.8]g/L,t=2.559,P＜0.05),oxygenation index([268.5±94.0]mmHg vs[323.2±120.9]mmHg,t=2.062,P＜0.05),and percentages of predicted diffusing capacity for carbon monoxide([30.9±15.3]% vs[44.9±18.8]%,t=2.127,P＜0.05])in the EBV DNA(+)group were significantly lower than those in the EBV DNA(-)group,while the levels of lactate dehydrogenase(LDH,[369.1±206.2]U/L vs[298.8±128.7]U/L,t=2.335,P＜0.05)were significantly higher than that in the EBV DNA(-)group.The acute exacerbation of ILD in the EBV DNA(+)group was more common than that in the EBV DNA(-)group(P＜0.05).Multivariate Lo-gistic analysis showed that honeycombing and low oxygenation index were independent risk factors of CTD-ILD patients complicated with EBV viraemia.Conclusion The CTD-ILD patients complicated with EBV viraemia have poorer oxygenation and are more prone to suf-fer from acute exacerbation of ILD.Honeycombing in chest HRCT and low oxygenation index are independent risk factors of CTD-ILD patients complicated with EBV viraemia.
