The expression of CTLA-4 and PD-L1 in pulmonary lymphoepithelial carcinoma,the clinical significance and the distribution of lymphocyte infiltration in the tumor microenvironment
10.13315/j.cnki.cjcep.2025.06.006
- VernacularTitle:CTLA-4和PD-L1在肺淋巴上皮癌中的表达、临床意义及其肿瘤微环境中淋巴细胞浸润的分布情况
- Author:
Jinli HUANG
1
;
Ruisi BEI
;
Yujiao CHEN
;
Zhimeng LI
;
Guiying HUANG
;
Yamin WEI
;
Jinhua ZHENG
Author Information
1. 桂林医学院附属医院病理科,桂林 541000
- Publication Type:Journal Article
- Keywords:
pulmonary lymphoepithelial carcinoma;
PD-L1;
CTLA-4;
tumor microenvironment;
immune checkpoints
- From:
Chinese Journal of Clinical and Experimental Pathology
2025;41(6):731-738
- CountryChina
- Language:Chinese
-
Abstract:
Purpose This study aimed to investigate the expression of CTLA-4 and PD-L1 in pulmonary lympho-epithelial carcinoma(PLEC)and to explore their relationships with patient prognosis and with tumor-infiltrating lym-phocytes(TILs).Methods Fifty cases of PLEC were retrospectively collected,together with 23 samples of adjacent normal lung tissue.Immunohistochemistry was performed to detect CTLA-4 and PD-L1 expression in both PLEC and adjacent normal lung tissues,as well as to quantify CD4+and CD8+T-lymphocytes infiltration within the tumor micro-environment.CTLA-4,PD-L1,and the distributions of CD4+T cells and CD8+T cells were then correlated with the clinicopathological features of PLEC.Results The positive rate of CTLA-4 in PLEC was significantly higher than that in adjacent normal lung tissue(P＜0.05).PD-L1 expression differed significantly across TNM stages of PLEC(P＜0.05)and was positively correlated with TNM stages(r=0.31,P=0.03).CD4+and CD8+T-lymphocytes were pre-dominantly localized in the tumor stroma,with CD4+T cells density exceeding that of CD8+(P＜0.05).Within canc-er nests,CD8+T cells density was significantly higher than CD4+(P＜0.05).Conclusion Both PD-L1 and CTLA-4 are frequently expressed in PLEC,suggesting they represent potential immunotherapeutic targets.In the PLEC micro-environment,lymphocytes primarily infiltrated the stromal compartment,and CD4+T cells are more abundant than CD8+T cells in that locale.
