Role of SPARC expression in the diagnosis and differential diagnosis of mesotheli-oma
10.13315/j.cnki.cjcep.2025.06.005
- VernacularTitle:SPARC表达在间皮瘤诊断和鉴别诊断中的作用
- Author:
Anli ZHANG
1
;
Xian WANG
;
Yuanzi YE
;
Can WU
;
Lanqing CHENG
;
Heng LI
;
Sibai SUN
;
Qiang WU
;
Haibo WU
Author Information
1. 中国科学技术大学附属第一医院(安徽省立医院)临床病理中心,合肥 230036
- Publication Type:Journal Article
- Keywords:
mesothelioma;
pulmonary poorly differentiated adenocarcinoma;
pulmonary poorly differentiated squamous cell carcinoma;
ovarian serous carcinoma;
SPARC
- From:
Chinese Journal of Clinical and Experimental Pathology
2025;41(6):726-730
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To investigate the role of secreted protein acidic and rich in cysteine(SPARC)expression in the diagnosis and differential diagnosis of mesothelioma.Methods Immunohistochemical EnVision two-step method was used to detect SPARC expression in 40 cases of mesothelioma,4 cases of well-differentiated mesothelial tumour(WDPMT),40 cases of poorly differentiated squamous cell carcinoma of the lung,40 cases of poorly differentiated ad-enocarcinoma of the lung,20 cases each of low-grade and high-grade serous carcinoma of the ovary.The sensitivity and specificity of SPARC,Calretinin,D2-40,and WT-1 expression in mesothelioma were compared and analyzed.Results SPARC showed diffuse strong positive expression in mesothelioma(37/40 cases),medium positive expression in WDPMT(3/4 cases),and focal weak positive expression in a few cases of poorly differentiated squamous cell carcino-ma of the lung(1/40 cases),poorly differentiated adenocarcinoma of the lung(2/40 cases),low-grade serous carci-noma of the ovary(0/20 cases),and high-grade serous carcinoma of the ovary(1/20 cases).In 40 mesotheliomas,the sensitivity of SPARC was 92.5％,and the specificity of SPARC in control tumors(squamous carcinoma of the lung,adenocarcinoma of the lung,and serous carcinoma of the ovary)was 96.7％.Conclusion SPARC is widely expressed in mesotheliomas,with a sensitivity similar to that of Calretinin,D2-40,and WT-1,but with a much higher specificity than other mesothelial markers.It is of great significance in distinguishing between mesothelioma and pulmo-nary poorly differentiated carcinoma and ovarian serous carcinoma.
