Effect of N-methyl-D-aspartic acid receptor in secondary visual cortex on methamphetamine-associated contextual learning and memory
10.3867/j.issn.1000-3002.2025.03.001
- VernacularTitle:次级视觉皮质N-甲基-D-天冬氨酸受体对甲基苯丙胺诱发情境关联学习记忆的影响
- Author:
Chu SUN
1
;
Danni CAO
;
Rui SONG
;
Jin LI
Author Information
1. 南京中医药大学,江苏南京 210023;军事医学研究院国家安全特需药品全国重点实验室,神经精神药理学北京市重点实验室,北京 100850
- Publication Type:Journal Article
- Keywords:
secondary visual cortex;
conditioned place preference;
methamphetamine;
N-methyl-D-aspartic acid receptor
- From:
Chinese Journal of Pharmacology and Toxicology
2025;39(3):161-168
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To investigate the effect of N-methyl-D-aspartic acid(NMDA)receptor in the secondary visual cortex(V2)on methamphetamine-associated contextual learning and memory.METHODS With male C57BL/6J mice as subjects and using the mouse conditioned place preference(CPP)experiment,the scores of CPP were observed after microinjection of NMDA receptor selective antagonist D-AP5(0.5 μg per side)into the bilateral V2 during the formation phase,single microinjec-tion of D-AP5(0.5 μg per side)into the bilateral V2 prior to the expression test,and methamphetamine(0.5 mg·kg-1,ip)-induced reactivation test and methamphetamine-associated contextual-induced reacti-vation test,to evaluate the effect of NMDA receptors on the formation,expression and reinstatement of methamphetamine-induced CPP.RESULTS Compared with the control group,microinjection of D-AP5(0.5 μg per side)into the bilateral V2 during the formation phase did not have significant inhibitory effect on CPP scores,nor did single microinjection of D-AP5(0.5 μg per side)into the bilateral V2 prior to the expression test,single microinjection of D-AP5(0.5 μg per side)into the bilateral V2 prior to metham-phetamine(0.5 mg·kg-1,ip)-induced reactivation test or single microinjection of D-AP5(0.5 μg per side)into the bilateral V2 prior to methamphetamine-associated contextual-induced reactivation test.CONCLU-SION The NMDA receptor in the V2 is not involved in the formation,expression and reactivation of meth-amphetamine-associated contextual learning and memory.
