Research progress in neuropsychiatric diseases therapy using vagus nerves
10.3867/j.issn.1000-3002.2025.03.008
- VernacularTitle:迷走神经在神经精神系统疾病治疗研究中的进展
- Author:
Han NI
1
;
Dujuan HE
;
Jingyao DUAN
;
Aibing CHEN
;
Liming ZHANG
Author Information
1. 河北科技大学化学与制药工程学院,河北 石家庄 050000;军事医学研究院,北京 100850
- Publication Type:Journal Article
- Keywords:
vagus nerve;
neurotransmitter;
immunity;
gut-brain axis;
depression
- From:
Chinese Journal of Pharmacology and Toxicology
2025;39(3):224-232
- CountryChina
- Language:Chinese
-
Abstract:
As the longest and most widely distributed pair of nerves in the brain,the vagus nerve is involved in the regulation of many systems and organs.Recent studies have found that the vagus nerve may be involved in the occurrence of a variety of neuropsychiatric diseases by regulating the release of neurotransmitters(such as norepinephrine,5-hydroxytryptamine,gamma-aminobutyric acid and acetylcholine)and regulating the immune system and gut-brain axis.This article focuses on the regulatory mechanisms of the vagus nerve on neurotransmitters,immune system function,and the gut-brain axis,as well the therapeutic advances in vagus nerve stimulation for neurological and psychi-atric diseases such as epilepsy,depression and anxiety disorders.
