Research progress of traditional Chinese medicine intervention in chemotherapy renal injury
10.12092/j.issn.1009-2501.2025.04.015
- VernacularTitle:中药干预化疗肾损伤研究进展
- Author:
Yeyuan LIU
1
;
Yafeng QI
;
Maofu ZHANG
;
Xinyu LI
;
Yanyun SHEN
;
Yu LIU
;
Shangzu ZHANG
;
Yangyang LI
;
Liying ZHANG
;
Zhiming ZHANG
Author Information
1. 甘肃中医药大学中医临床学院,兰州 730000,甘肃
- Publication Type:Journal Article
- Keywords:
chemotherapy;
kidney injury;
mecha-nism;
traditional Chinese medicine;
research prog-ress
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2025;30(4):556-569
- CountryChina
- Language:Chinese
-
Abstract:
Renal injury is one of the common ad-verse reactions in the clinical application of chemo-therapy drugs,which is the main reason why the chemotherapy can not be carried out in the whole cycle.The pathological mechanism of chemothera-py-induced renal injury is very complicated,mainly involving oxidative stress,inflammatory response,apoptosis,mitochondrial dysfunction,and regula-tion of transporters,causing pathological damage to renal tubules or glomeruli.At present,there is no specific pharmacological intervention for the treatment of chemotherapy-induced renal injury.As a treasure of traditional Chinese medicine,tradi-tional Chinese medicine has the advantages of overall regulation,multi-targeting,small adverse re-actions and no obvious drug dependence in the prevention and treatment of chemotherapy-in-duced renal injury.In recent years,there have been more and more studies on the intervention of che-motherapy-induced renal injury by multi-compo-nent and multi-directional intervention of active components,extracts and compounds of tradition-al Chinese medicine,and some progress has been made.A large number of studies have shown that the potential mechanisms of traditional Chinese medicine in preventing and treating renal injury in-duced by chemotherapy include inhibiting oxida-tive stress,reducing inflammatory response and in-hibiting apoptosis.Although there are many stud-ies on the mechanism of action of traditional Chi-nese medicine in the treatment of chemotherapy-induced renal injury,there is still a lack of systemat-ic review.Based on this,this paper summarizes the mechanism of renal injury induced by chemothera-py and the intervention of traditional Chinese medi-cine,so as to provide theoretical support for its clinical treatment and new drug innovation.
