SPP1 expression in SMARCA4-deficient non-small cell lung cancer and its relationship with PD-L1
10.12092/j.issn.1009-2501.2025.04.005
- VernacularTitle:SMARCA4缺失型非小细胞肺癌的SPP1表达及其与PD-L1的关系
- Author:
Juan WU
1
;
Xi HUANG
;
Jiajia LI
;
Yuqing WEI
;
Liqing ZHANG
;
Yongmei YU
;
Zhiwei LU
;
He ZHANG
Author Information
1. 皖南医学院病理生理学教研室,芜湖 241000,安徽
- Publication Type:Journal Article
- Keywords:
NSCLC;
SMARCA4 deficient;
SPP1;
PD-L1;
immunotherapy
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2025;30(4):477-486
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To analyze the expression of se-creted phosphoprotein 1(SPP1)and programmed cell death-ligand 1(PD-L1)in SMARCA4-deficient non-small cell lung cancer,and to provide a scientif-ic basis for the study of the follow-up treatment of this rare pathological type of lung cancer.METH-ODS:The clinical and pathological characteristics of 12 patients with this disease were analyzed retro-spectively,and the patients were divided into two groups of adenocarcinomas and poorly differentiat-ed carcinomas according to their morphological characteristics,and the relationship between the expression of SPP1 and PD-L1 was analyzed in the two groups.RESULTS:SPP1 expression was detect-ed in all patients and Its expression level was signif-icantly higher in the poorly differentiated carcino-ma group compared with the adenocarcinoma group(P=0.015);PD-L1 expression was found in 6/7 patients(5 cases were not measured),compared with the adenocarcinoma group,PD-L1 was also highly expressed in the poorly differentiated carci-noma group(P=0.048)and the PD-L1 difference be-tween the two groups suggested that the results were similar to those of SPP1.CONCLUSION:SMARCA4-deficient non-small cell lung cancer has high positive expression of SPP1 and PD-L1.It was more pronounced in patients with poorly differenti-ated carcinoma.There may be a positive correla-tion between SPP1 and PD-L1 expression in SMAR-CA4-deficient non-small cell lung cancer and the mechanism of the correlation needs to be further verified in subsequent studies.
