Association of white blood cell count with venous thromboembo-lism:a two-way Mendelian randomization study
10.12092/j.issn.1009-2501.2025.04.002
- VernacularTitle:白细胞计数与静脉血栓栓塞的关联:双向孟德尔随机化研究
- Author:
Zhanli GUO
1
;
Yuan WANG
;
Lei ZHANG
;
Jiayuan LI
;
Ruoning LI
;
Ying DONG
;
Jianjun SUN
Author Information
1. 内蒙古医科大学药学院,呼和浩特 010059,内蒙古
- Publication Type:Journal Article
- Keywords:
venous thromboembolism;
thrombo-embolic disease;
white blood cell count;
Mendelian randomization
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2025;30(4):446-455
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To explore the causal association between the counts of five types of white blood cells—neutrophils,monocytes,eosinophils,baso-phils,and lymphocytes—and venous thromboem-bolism(VTE).METHODS:Mendelian randomization(MR)analysis method was used,with genetic vari-ants associated with the five types of white blood cells as instrumental variables,and venous throm-boembolism occurrence risk as the outcome vari-able,inverse variance-weighted(IVW)method was employed as the primary analysis method,with MR-Egger regression,weighted median(WM),sim-ple model,and weighted mode methods used as supplements,to analyze the causal association be-tween the counts of five types of white blood cells and VTE,followed by reverse MR analysis.RE-SULTS:Neutrophil and lymphocyte counts are caus-ally associated with the risk of VTE.For neutrophil count,the IVW estimate(OR=0.867,95%CI:0.761-0.981,P=0.031),MR-Egger estimate(OR=0.754,95%CI:0.571-0.996,P=0.048),weighted median es-timate(OR=0.846,95%CI:0.729-0.981,P=0.027),and weighted model estimate(OR=0.748,95%CI:0.595-0.942,P=0.014)were calculated.For lympho-cyte count,the IVW estimate(OR=0.838,95%CI:0.741-0.949,P=0.005)and weighted median esti-mate(OR=0.024,95%CI:0.718-0.977,P=0.024)were calculated.Reverse MR analysis showed a causal association between the risk of VTE and neu-trophil count,the IVW estimate(OR=0.989,95%CI:0.980-0.999,P=0.024).CONCLUSION:Neutrophil and lymphocyte counts are related to the risk of VTE,and decrease in neutrophil and lymphocyte numbers may increase the risk of VTE.VTE occur-rence risk is associated with neutrophil count,and reducing the risk of VTE occurrence may increase neutrophil count.Further research is needed to un-derstand the underlying biological mechanisms be-hind this relationship.
