Research progress on the role of macrophage polarization in cardio-vascular diseases
10.12092/j.issn.1009-2501.2025.04.014
- VernacularTitle:巨噬细胞极化与心血管疾病研究进展
- Author:
Hanyu CUI
1
;
Changping HU
1
Author Information
1. 中南大学湘雅药学院药理学系,心血管研究湖南省重点实验室,长沙 410078,湖南
- Publication Type:Journal Article
- Keywords:
macrophage polarization;
inflamma-tion;
cardiovascular diseases;
transcriptional regula-tion
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2025;30(4):548-555
- CountryChina
- Language:Chinese
-
Abstract:
As phagocytic innate immune cells,macrophages interact with various tissue types and play an important role in immune defense,inflam-matory response and tissue remodeling.Macro-phages participate in the occurrence and develop-ment of disease by polarizing into classically acti-vated M1 type and substitutively activated M2 type,or more complex phenotypes,when the tis-sue microenvironment changes.This paper focused on the application of macrophage polarization in cardiovascular diseases,and introduces macro-phage origin and activation to propose the relation-ship between macrophage polarization and cardio-vascular diseases.Then,the strategies for targeted macrophage therapy were proposed to provide an important theoretical basis for improving the in-flammatory state of cardiovascular diseases.
