Research progress of epigenetics in the pathogenesis of depression
10.12092/j.issn.1009-2501.2025.04.010
- VernacularTitle:表观遗传学在抑郁症发病机制中的研究进展
- Author:
Yao ZHANG
1
;
Manshu ZOU
;
Yuanshan HAN
;
Yuhong WANG
Author Information
1. 湖南中医药大学科技创新中心,长沙 410208,湖南
- Publication Type:Journal Article
- Keywords:
depression;
epigenetics;
DNA methyl-ation;
histone modification;
noncoding RNA regula-tion;
chromatin remodeling
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2025;30(4):517-525
- CountryChina
- Language:Chinese
-
Abstract:
Depression is a mental disease with in-creasing prevalence worldwide,which seriously en-dangers human health with high disability rate and high suicide rate.Epigenetics is an emerging genet-ic theory in the 21st century.Its main research con-tent is to regulate the process of gene transcription or translation and affect its function and character-istics without changing the DNA sequence.These include DNA methylation,histone modification,chromatin remodeling and non-coding RNA regula-tion.The nervous system is susceptible to changes in the activity of epigenetic modifiers,and an in-creasing number of studies have shown that genet-ics and environment play an important role in the development of depression.This review will focus on the epigenetic mechanisms of depression.
