The relationship between NLRC4-mediated inflammasome pathway and multiple myeloma and its therapeutic prospect
10.12092/j.issn.1009-2501.2025.04.008
- VernacularTitle:NLRC4介导的炎症小体通路与多发性骨髓瘤的关系及治疗前景
- Author:
Tingting XU
1
;
Wanjie WANG
1
;
Jing BAO
1
;
Ruixiang XIA
1
Author Information
1. 安徽医科大学第一附属医院血液科,合肥 230032,安徽
- Publication Type:Journal Article
- Keywords:
multiple myeloma;
inflammasome;
NLRC4;
treatment plan;
clinical prognosis
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2025;30(4):501-508
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To explore the mechanism of ac-tion and clinical significance of NLRC4 in multiple myeloma by analyzing the relative expression and clinical significance of NLRC4 mRNA in bone mar-row fluid of patients with multiple myeloma(MM),so as to guide the formulation of disease treatment and the evaluation of clinical prognosis.METHODS:MMRF database and GTEx database were used to compare the expression and survival correlation of inflammatory bodies between myeloma patients and normal controls.Real-time fluorescent quanti-tative polymerase chain reaction(qPCR)was used to detect the expression of inflammatory bodies in bone marrow fluid of 26 newly diagnosed myeloma patients and 19 post-treatment myeloma patients and peripheral blood of 28 normal volunteers ad-mitted to the First Affiliated Hospital of Anhui Medi-cal University from January to September 2023.The mRNA expression differences of each inflammatory body and the correlation between NLRC4 inflamma-tory body expression and clinicopathologic fea-tures,inflammatory factor/chemokine expression of newly diagnosed patients were analyzed.RE-SULTS:Compared with the control group and the treatment group,the expression of inflammasome mRNA in the newly diagnosed group was increased except for NLRP3,and the expression of NLRC4 mRNA was significantly increased(P<0.01).The he-moglobin count,creatinine level and calcium ion level were linearly correlated with NLRC4 mRNA ex-pression level in newly diagnosed patients(P<0.05).The mRNA expression levels of IL-18,CCL-3 and NL-RC4 in newly diagnosed patients were linearly cor-related(P<0.05).CONCLUSION:NLRC4 inflammato-somes are highly expressed in MM,and promote the occurrence and development of tumor by pro-moting the production and release of inflammatory cytokines/chemokines IL-18 and CCL-3,which is of great significance for the formulation of treatment plan and clinical prognosis evaluation of multiple myeloma.
