Progress in role of mitophagy in atherosclerosis
10.3969/j.issn.1000-4718.2025.03.020
- VernacularTitle:线粒体自噬在动脉粥样硬化中作用的研究进展
- Author:
Biao ZHENG
1
;
Qiong WANG
;
Yubo XIAO
;
YuanJie XIE
;
Zhongcheng MO
Author Information
1. 广西糖尿病系统医学重点实验室,桂林医学院组织学与胚胎学教研室,广西 桂林 541199
- Publication Type:Journal Article
- Keywords:
atherosclerosis;
mitophagy;
macrophages;
vascular endothelial cells;
vascular smooth muscle cells
- From:
Chinese Journal of Pathophysiology
2025;41(3):585-592
- CountryChina
- Language:Chinese
-
Abstract:
Mitophagy,a special form of selective autophagy,plays a significant role in the pathogenesis of atherosclerosis by regulating cellular lipid metabolism,inflammation,and oxidative stress.However,its regulatory mech-anism is complex and has not been fully elucidated.Notably,many drugs and herbal ingredients exhibit anti-atherosclerot-ic effects by modulating mitophagy in macrophages,vascular endothelial cells,and vascular smooth muscle cells,offering potential new avenues for the prevention and treatment of atherosclerosis.In this article,we review the role of mitophagy in regulating cellular functions and the progression of atherosclerosis,as well as summarize potential therapeutic drugs that may contribute to anti-atherosclerosis by modulating mitophagy.Our aim is to provide a new literature basis for further ex-ploration of the role of mitophagy in atherosclerosis.
