Progress in role and mechanism of branched-chain amino acid metabo-lism in myocardial regeneration
10.3969/j.issn.1000-4718.2025.03.019
- VernacularTitle:支链氨基酸代谢在心肌再生中作用及机制的研究进展
- Author:
Duanrui CAO
1
;
Lina HUANG
1
;
Xinhua YAO
1
;
Ni ZHANG
1
Author Information
1. 江西中医药大学药学院,江西 南昌 330004
- Publication Type:Journal Article
- Keywords:
heart failure;
branched-chain amino acid metabolism;
myocardial regeneration
- From:
Chinese Journal of Pathophysiology
2025;41(3):577-584
- CountryChina
- Language:Chinese
-
Abstract:
Myocardial infarction(MI)is the leading cause of mortality worldwide,with heart failure(HF)af-ter MI being the main driver of this high mortality rate.Currently,no method can effectively halt the progression from MI to HF.In recent years,research on myocardial regeneration has shown promise for the treatment of HF after MI.Studies have confirmed that the regulation of myocardial amino acid metabolism can achieve myocardial regeneration,and branched-chain amino acid(BCAA)metabolism is crucial for this process.BCAA can regulate the branched-chain keto acid level through the BCAA aminotransferase(BCAT)-branched-chain keto acid dehydrogenase(BCKDH),BCKDH ki-nase(BCKDK)-BCKDH,and mitochondrial protein phosphatase 2C(PP2Cm)-BCKDH axes,thereby activating the mam-malian target of rapamycin to promote myocardial regeneration.BCAA also participates in the crosstalk between glucose and lipid metabolism,reprogramming fatty acid oxidation towards glucose metabolism and inducing cardiomyocyte prolifer-ation.However,the effects of BCAA on myocardial regeneration have not been systematically reviewed.In this review,the relationship and underlying mechanism between BCAA and myocardial regeneration are discussed extensively from the perspective of amino acid metabolic reprogramming,providing a reference for the study and treatment of post-MI HF.
