Clinical Study on the Therapeutic Effect of Shen-Fu Injection on Gastrointestinal Dysfunction in Patients with Septic Shock
10.11969/j.issn.1673-548X.2025.05.023
- VernacularTitle:参附注射液对脓毒性休克患者胃肠功能障碍疗效的临床研究
- Author:
Ziqian YUAN
1
;
Sen WANG
;
Qiliang HOU
Author Information
1. 730000 兰州大学第一临床医学院
- Publication Type:Journal Article
- Keywords:
Septic shock;
Shen-Fu injection;
Gastrointestinal dysfunction;
Prognosis
- From:
Journal of Medical Research
2025;54(5):124-128
- CountryChina
- Language:Chinese
-
Abstract:
Objective The study aimed to investigate the effect of Shen-Fu injection on the clinical efficacy and prognosis of gas-trointestinal dysfunction in patients with septic shock.Methods Patients diagnosed with septic shock in the Department of Critical Care Medicine of the First Hospital of Lanzhou University from September 2021 to April 2024 were enrolled and divided into the Shen-Fu group and the conventional treatment group according to the treatment plan.The propensity score matching(PSM)was used for 1∶1 matc-hing.Clinical data of patients in both groups at enrollment,the main gastrointestinal symptoms(vomiting,diarrhea,abdominal disten-sion,abnormal bowel sounds,gastric retention),blood lactic acid(Lac),interleukin(IL)-6,procalcitonin(PCT),white blood cell(WBC),neutrophil percentage(NEUT％),the ratio of lactic acid to creatinine(Lac/SCr)before and 5days after treatment,and the mortality rate 28days after discharge were recorded.Results Compared with conventional treatment group(35.06％),the total effective rate(66.23％)of gastrointestinal efficacy in Shen-Fu group 5days after treatment was significantly higher(x2=14.964,P＜0.05).The levels of Lac,WBC and Lac/SCr in Shen-Fu group was higher than that in conventional treatment group(P＜0.05).There was no significant difference in IL-6,PCT and NEUT％(P＞0.05).Compared with pre-treatment,the levels of IL-6,Lac,Lac/SCr de-creased after 5days of treatment in Shen-Fu group(P＜0.05),while there was no significant difference in PCT,WBC and NEUT％(P＞0.05).There was no statistically significant difference in mortality rate between the two groups at 28 days after discharge(P＞0.05).Conclusion Shen-Fu Injection can improve gastrointestinal dysfunction in patients with septic shock,alleviate gastrointestinal symptoms,suppress inflammatory responses,enhance gastrointestinal tissue perfusion,and can improve the short-term prognosis of pa-tients with septic shock to some extent.
