Endovascular intervention technology for constructing canine models of hepatic vein obstruction type Budd-Chiari syndrome
10.13929/j.issn.1672-8475.2025.03.012
- VernacularTitle:血管腔内介入技术用于构建肝静脉阻塞型巴德-基亚里综合征犬模型
- Author:
Xuedong SUN
1
;
Feng DUAN
;
Chao MA
;
Zhenfei SONG
;
Maoqiang WANG
;
Long JIN
Author Information
1. 首都医科大学附属北京友谊医院放射介入科,北京 100050
- Publication Type:Journal Article
- Keywords:
Budd-Chiari syndrome;
hepatic veno-occlusive disease;
dogs;
model,animal
- From:
Chinese Journal of Interventional Imaging and Therapy
2025;22(3):205-209
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the feasibility of endovascular intervention technology for constructing canine models of hepatic vein(HV)obstruction type Budd-Chiari syndrome(BCS).Methods HV obstruction type BCS models were established through double approaches including external jugular vein and percutaneous transhepatic vein puncture,blocking the main HV with double balloon and injecting anhydrous ethanol using 10 Beagle dogs.Laboratory indexes before and after modeling were compared.Liver ultrasound was performed 2,4 and 8 weeks after modeling,respectively,while intravascular ultrasound(IVUS)and digital subtracting angiography(DSA)were performed after the last time ultrasound to observe the obstruction degree,lumen and blood flow of left hepatic vein(LHV).The stenosis rate of LHV was evaluated based on DSA findings,and successful establishment of HV obstruction type BCS canine model was regarded as stenosis rate＞30%and incomplete occlusion of LHV,then the success rate of modeling was recorded.Results No significant difference of laboratory indexes was found before and after modeling(all P＞0.05).Ultrasound,IVUS and DSA showed that after modeling,different degrees of LHV stenosis complicated with intrahepatic collateral circulation were found in 9 dogs,while complete occlusion of LHV was noticed in 1 dog.The success rate of modeling was 90.00%(9/10).Pathological results showed the target HV lumen narrow with thickened endovascular wall,and the latter mainly composed of fibroblast and collagen fiber proliferation.Conclusion Endovascular intervention technology was feasible for constructing canine models of HV obstruction type BCS.
