Role of bile acid metabolism in occurrence and development of metabolic cardiovascular and cerebrovascular diseases
10.3969/j.issn.1000-4718.2025.00.006
- VernacularTitle:胆汁酸代谢在代谢性心脑血管疾病发生发展中的作用
- Author:
Wanyue YANG
1
;
Xinyi ZHANG
;
Yang YU
Author Information
1. 山东第一医科大学(山东省医学科学院)实验动物学院(省实验动物中心),山东 济南 250117;山东第一医科大学(山东省医学科学院)临床与基础医学院,山东 济南 250117
- Publication Type:Journal Article
- Keywords:
bile acid;
lipid metabolism;
cardiovascular diseases;
cerebrovascular diseases
- From:
Chinese Journal of Pathophysiology
2025;41(3):569-576
- CountryChina
- Language:Chinese
-
Abstract:
Bile acids,as important signaling molecules,regulate a complex metabolic network by binding to various membrane receptors and nuclear receptors such as farnesoid X receptor(FXR),Takeda G protein-coupled recep-tor 5(TGR5),and sphingosine-1-phosphate receptor 2(S1PR2).Studies have shown that bile acids are closely related to the occurrence and development of various metabolic cardiovascular and cerebrovascular diseases.For instance,activa-tion of TGR5 can reduce foam cell formation and atherosclerotic lesions,FXR modulates lipid metabolism by inhibiting genes of triglyceride synthesis,and ursodeoxycholic acid effectively reduces pro-inflammatory cytokines,improves peripheral microcirculation and decreases the risk of heart failure.This study provides an overview of the biosynthesis and metabo-lism of bile acids,the pathways and functions of major bile acid receptors,and the relationship between bile acids and the development of cardiovascular and cerebrovascular diseases,aiming to offer a reference for mechanistic research and drug development targeting bile acid receptors.
