Progress in role of interaction between mitophagy and NLRP3 inflamma-some in diabetic retinopathy injury
10.3969/j.issn.1000-4718.2025.03.022
- VernacularTitle:线粒体自噬与NLRP3炎症小体的相互作用在糖尿病视网膜病变中作用的研究进展
- Author:
Yishan WANG
1
;
Xiangxia LUO
1
;
Li SU
1
;
Qing LIU
1
Author Information
1. 甘肃省中医院眼科,甘肃 兰州 730000
- Publication Type:Journal Article
- Keywords:
diabetic retinopathy;
mitophagy;
NLRP3 inflammasome
- From:
Chinese Journal of Pathophysiology
2025;41(3):600-605
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic retinopathy(DR)is one of the common serious microvascular complications in diabetic patients,with the main pathological features of retinal vascular injury,oxidative stress and chronic inflammatory re-sponse.In recent years,more and more studies have shown that mitophagy plays an important role in maintaining the func-tional homeostasis of retinal cells and preventing oxidative damage,and nucleotide-binding oligomerization domain-like re-ceptor protein 3(NLRP3)is a key regulator of pro-inflammatory response in DR.Mitophagy can reduce the excessive pro-duction of reactive oxygen species(ROS)by removing damaged mitochondria,thereby inhibiting the activation of NLRP3 inflammasome.In contrast,mitochondrial dysfunction can lead to excessive activation of NLRP3 inflammasome,which further aggravates the inflammatory response and apoptosis of the retina.Therefore,this article reviews the independent role of mitophagy and NLRP3 inflammasome in DR and their mutual regulatory mechanisms,so as to provide reference for the study of mitophagy and NLRP3 inflammasome as targets.
