Prognostic Analysis of Leptomeningeal Metastasis in Lung Adenocarcinoma with Negative Driver Gene
10.11969/j.issn.1673-548X.2025.05.020
- VernacularTitle:驱动基因阴性的肺腺癌软脑膜转移预后分析
- Author:
Jing LUO
1
;
Jie TAO
;
Yan ZHANG
Author Information
1. 830011 乌鲁木齐,新疆医科大学第三临床医学院
- Publication Type:Journal Article
- Keywords:
Lung adenocarcinoma;
Meningeal metastasis;
Prognosis
- From:
Journal of Medical Research
2025;54(5):105-109,123
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the prognostic factors of leptomeningeal metastasis of lung adenocarcinoma without driving gene.Methods Retrospectively collected the clinical data of lung adenocarcinoma patients with leptomeningeal metastasis without driving gene in the affiliated Cancer Hospital of Xinjiang Medical University from January 1,2011 to December 31,2023,and followed up their survival time.Results Among the 58 patients with leptomeningeal metastasis of lung adenocarcinoma,the survival time was 0-38.0months,the median overall survival time(mOS)was 5.0months,and the one-year survival rate was 25.9％.33 patients received antineoplastic therapy,and the survival time of patients receiving antineoplastic therapy was significantly longer than that of patients with-out antineoplastic therapy(8.0months vs 2.0months,P=0.006).Among them,12 patients received chemotherapy combined with whole brain radiotherapy.The mOS of patients who received chemotherapy combined with radiotherapy and those who did not receive chemother-apy combined with radiotherapy were 6.0 and 3.0months(P=0.098).21 patients received only systemic chemotherapy,and the mOS of patients receiving chemotherapy alone and chemotherapy combined with radiotherapy were 6.0 and 8.0months(P=0.497).The survival time of patients less than 60 years old at the time of diagnosis of LM was prolonged(8.0months vs 2.0months,P=0.011).Whether pa-tients received antineoplastic therapy or not was an independent prognostic factor for patients with lung adenocarcinoma LM(HR=0.489,95％CI:0.281-0.849).Conclusion Age＜60 years old and antineoplastic therapy can prolong the prognosis of patients with lepto-meningeal metastasis of lung adenocarcinoma with negative driver gene,and antineoplastic therapy is an independent factor affecting the prognosis of patients.
