Predictive Value of Serum Bilirubin Levels on Renal Injury in Children with IgA Vasculitis
10.11969/j.issn.1673-548X.2025.05.017
- VernacularTitle:血清胆红素水平变化在IgA血管炎儿童发生肾损伤中的预测价值
- Author:
Wanying ZHU
1
;
Lingchao WANG
1
;
Na WEI
1
Author Information
1. 453100 新乡医学院第一附属医院
- Publication Type:Journal Article
- Keywords:
Serum bilirubin;
IgA vasculitis;
Nephritis;
Children
- From:
Journal of Medical Research
2025;54(5):88-92
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the changes in serum bilirubin levels in children with IgA vasculitis(IgAV)nephritis(IgAVN)and its role in the diagnosis of IgAVN.Methods The clinical data of 134 patients with IgAV who were admitted to the First Affiliated Hospital of Xinxiang Medical College from October 2021 to July 2023 were retrospectively analyzed.They were divided into IgAV group(89 cases)and IgAVN group(45 cases)according to the presence or absence of renal involvement.During the same period,40 children with idiopathic short stature who were hospitalized for examination were selected as the control group.Variance analysis was used to statis-tically analyze the differences in clinical parameters and serum total bilirubin levels among the groups.Spearman correlation analysis and multivariate Logistic regression analysis were used to evaluate the correlation of the parameters.ROC curve was used to evaluate the sensi-tivity and specificity of diagnosis.Results The levels of TBIL and IBIL in the IgAV and IgAVN groups were significantly lower than those in the control group(P＜0.05),and the levels of TBIL,IBIL and DBIL in the IgAVN group were significantly lower than those in the IgAV group(P＜0.05).TBIL and IBIL levels were negatively correlated with IgAVN.The specificity of TBIL and IBIL for diagnosing IgAVN was 86.5％and 68.5％,with sensitivities of 46.7％and 51.1％,respectively.When combined with other variables,the serum bilirubin prediction model achieved an AUC of 0.817(95％CI:0.744-0.891,P＜0.001),with a sensitivity of 79.8％and specificity of 66.7％.Conclusion The determination of serum bilirubin level has a certain clinical value in predicting the occurrence of renal in-volvement(IgAVN)in children with IgAV.
