Predictive Value of Naples Prognostic Score Combined with Fibrinogen Albumin Ratio for the Prognosis of Sepsis Patients
10.11969/j.issn.1673-548X.2025.05.030
- VernacularTitle:NPS联合FAR对脓毒症患者预后的预测价值
- Author:
Maoming LIU
1
;
Guohui YANG
1
Author Information
1. 550001 贵阳,贵州医科大学临床医学院
- Publication Type:Journal Article
- Keywords:
Naples prognostic score;
Fibrinogen-to-albumin-ratio;
Sepsis;
Septic shock
- From:
Journal of Medical Research
2025;54(5):174-179,202
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the predictive value of Naples Prognostic Score(NPS)combined with Fibrinogen Albumin Ratio(FAR)for the prognosis of sepsis patients.Methods A retrospective analysis was conducted on the clinical data of sepsis patients ad-mitted to the Medical Intensive Care Unit(MICU)of Guizhou Medical University Affiliated Hospital between January 2019 and January 2024.Based on 28-day clinical outcomes,these patients were divided into a survival group and a death group.Differences in NPS,FAR,and the combined scores of NPS and FAR were compared between the two groups.The predictive performance of NPS,FAR,and NPS+FAR for prognosis was evaluated using Receiver Operating Characteristic(ROC)curves and Decision Curve Analysis(DCA).Results This study enrolled a total of 245sepsis patients.Following a 28-day clinical observation,there were 140 patients in the surviv-al group and 105 in the death group.Significant differences(P＜0.05)were observed in fibrinogen(Fg),albumin,FAR,NPS,Acute Physiology and Chronic Health Evaluation Ⅱ(APACHE Ⅱ),and Sequential Organ Failure Assessment(SOFA)scores between the two groups.Multivariate Logistic regression analysis indicated that SOFA,APACHE Ⅱ,FAR and NPS were independent risk factors for poor prognosis in sepsis patients(P＜0.05).NPS(with an area under the ROC curve of 0.738)and FAR(with an area under the ROC curve of 0.755)exhibited good predictive value for the 28-day prognosis of sepsis patients.However,the combined score of NPS+FAR(with an area under the ROC curve of 0.812)proved to be a more accurate predictor of 28-day prognosis in sepsis patients compared to NPS or FAR alone.Additionally,the triple index,which includes NPS+FAR,SOFA,and APACHE Ⅱ(with an area under the ROC curve of 0.930),significantly enhanced the predictive value for 28-day mortality in sepsis patients.Conclusion NPS,FAR,and the combi-nation of NPS and FAR have good predictive value for adverse outcomes in sepsis at 28days.
