Effect of Angiotensin Receptor Blocker on Acute Kidney Injury after Acute Ischemic Stroke
10.11969/j.issn.1673-548X.2025.05.026
- VernacularTitle:血管紧张素受体阻滞剂对急性缺血性脑卒中后并发急性肾损伤的影响
- Author:
Pan ZHANG
1
;
Dawei CHEN
1
;
Xin WAN
1
Author Information
1. 210006 南京医科大学附属南京医院肾内科
- Publication Type:Journal Article
- Keywords:
Acute kidney injury;
Acute ischemic stroke;
Angiotensin receptor blocker;
Propensity score matching
- From:
Journal of Medical Research
2025;54(5):141-147
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of angiotensin receptor blocker(ARB)on the occurrence of acute kidney injury(AKI)after acute ischemic stroke.Methods From January 2022 to July 2023,patients with acute ischemic stroke hospitalized in the department of neurology of Nanjing First Hospital were enrolled.A 1∶1 propensity score matching method was adopted to evaluate the effect of ARB on the occurrence of AKI in patients with acute ischemic stroke.Results According to the inclusion and exclusion criteria,919 patients were enrolled,among whom 182developed AKI,with an incidence rate of 19.8％.Compared with patients without AKI,those with AKI were older and had a higher proportion of hypertension,diabetes,coronary heart disease,and heart failure.They were ad-mitted with lower Glasgow coma scale(GCS)score and higher National Institute of Health Stroke Scale(NIHSS)score.In terms of labo-ratory test data,patients with AKI had higher white blood cell counts,serum creatinine,and lower hemoglobin,albumin,low-density lipoprotein,and total cholesterol.Additionally,patients with AKI underwent a higher proportion of endovascular treatments,used diuret-ics,and received mannitol.After matching propensity score,patients using ARB had a lower incidence of AKI(17.1％vs 25.0％,P=0.044)and a lower mortality rate(1.2％vs 5.8％,P=0.014)than those without ARB.There were no significant differences between the two groups in terms of renal replacement therapy,intensive care unit,and the length of hospital stay.Conclusion ARB may have a potential protective effect on the occurrence of AKI after acute ischemic stroke.
