Balance of T Helper Cell 17 and T Regulatory Cell:A New Target for Obesity Treatment
10.3870/j.issn.1672-0741.24.09.022
- VernacularTitle:Th17/Treg细胞平衡:治疗肥胖的新靶点
- Author:
Yingxin WU
1
;
Wenyan WANG
Author Information
1. 湖北中医药大学针灸骨伤学院,武汉 430061
- Publication Type:Journal Article
- Keywords:
obesity;
helper T cell;
regulatory T cell;
Th17/Treg cell balance
- From:
Acta Medicinae Universitatis Scientiae et Technologiae Huazhong
2025;54(3):452-457
- CountryChina
- Language:Chinese
-
Abstract:
In the general state,Th17 cells can promote inflammatory responses,while Treg cells have anti-inflammatory and immunomodulatory functions.In obesity individuals,the body is often in a chronic low-grade inflammatory state,and the Th17/Treg cell balance is disrupted,leading to an increase in the number and hyperfunction of Th17 cells and a decrease in the number and hypofunction of Treg cells,which exacerbates the development of obesity and related metabolic diseases.In this paper,the relationship between Th17/Treg cell balance and obesity,and the mechanism of Th17/Treg cell imbalance leading to the occur-rence and development of obesity are reviewed according to relevant research progress in recent years,with a view to exploring new targets for the treatment of obesity.
