Imaging manifestation of post-transplant lymphoproliferative disorder associated with EB virus after allogeneic hematopoietic stem cell transplantation
10.3969/j.issn.1002-1671.2025.04.033
- VernacularTitle:血液病异基因造血干细胞移植后EB病毒相关性淋巴组织增殖性疾病的影像表现
- Author:
Lianbo LI
1
;
Yuzhu SHI
;
Li LI
;
Ke QIU
Author Information
1. 河北燕达陆道培医院影像科,河北 三河 065201
- Publication Type:Journal Article
- Keywords:
blood disease;
hematopoietic stem cell transplantation;
lymphoproliferative disorder;
computed tomography;
magnetic resonance imaging
- From:
Journal of Practical Radiology
2025;41(4):687-690
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the imaging features of post-transplant lymphoproliferative disorder(PTLD)after allogeneic hematopoietic stem cell transplantation(allo-HSCT).Methods The imaging findings of EB virus-associated PTLD(EBV-PTLD)after allo-HSCT in 8 patients with hematological diseases were retrospectively analyzed,including 1 case with acute lymphoblastic leukemia(ALL),3 cases with acute myeloid leukemia(AML),1 case with myelodysplastic syndrome(MDS)and 3 cases with aplas-tic anemia(AA).All patients were positive for EB virus(EBV)after transplantation.MRI,CT plain scan and enhanced scan were performed to analyze the imaging features of all lesions.Results Central nervous system(CNS)was involved in 5 cases,pharyngeal lymphatic ring and left lacrimal sac was involved in 1 case,liver was involved in 1 case,intraperitoneal and retroperitoneal lymph nodes was involved in 1 case.All patients were pathologically confirmed with PTLD.Conclusion PTLD may involve multiple organs and tissues after hematopoietic stem cell transplantation with different onset time.Timely MRI and CT examination,combined with PTLD screening and EBV detection,can detect and diagnose PTLD lesions in early stage,providing important clinical value.
