Analyse of the Influencing Factors and Prediction Model Construction of Pregnancy Outcome of Test-Tube Baby Assisted Pregnancy Based on Clinical Data
10.13241/j.cnki.pmb.2025.12.018
- VernacularTitle:基于临床资料分析试管婴儿辅助助孕妊娠结局的影响因素及预测模型构建
- Author:
Yan-ni HUANG
1
;
Shun LI
1
;
Jing WEI
1
Author Information
1. 柳州市人民医院生殖医学科 广西柳州 545006
- Publication Type:Journal Article
- Keywords:
Clinical data;
Test-tube baby;
Assisted pregnancy;
Infertility;
Pregnancy outcome;
Predictive model
- From:
Progress in Modern Biomedicine
2025;25(12):2048-2054
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the influencing factors of pregnancy outcome of test-tube baby assisted pregnancy base on clinical data,and build a prediction model.Methods:The clinical data of 283 infertility patients were retrospectively analyzed.They were divided into successful pregnancy group(147 cases)and failed pregnancy group(136 cases)according to the pregnancy outcome.The influencing factors of pregnancy were analyzed by multivariate Logistic regression analysis.The predictive value of influencing factors was evaluated by drawn receiver operating characteristic(ROC)curve.Prediction model was constructed and verified based on the results of multivariate Logistic regression analysis.Results:283 cases of infertility patients received test-tube baby assisted pregnancy treatment,147 cases were successfully pregnant,and the pregnancy success rate was 51.94％(147/283).The proportion of the duration of infertility＞3 years,the proportion of endometrial morphology on HCG injection day was B or C,the proportion of endometrial thickness＜7 mm,and the proportion of embryo quality not good in failed pregnancy group were higher than those in successful pregnancy group(P＜0.05).Endometrial thickness＜7 mm,endometrial morphology on HCG injection day was B or C,the duration of infertility＞3 years,embryo quality not good were the risk factors for the failure of test-tube baby assisted pregnancy(P＜0.05).The results of ROC curve analysis showed that,the area under the curve(AUC)of endometrial morphology on HCG injection day,the duration of infertility,endometrial thickness and embryo quality to predict the failure of test-tube baby assisted pregnancy were 0.577,0.617,0.581 and 0.603 respectively.Multivariate Logistic regression model was constructed based on the influencing factors of failure of test-tube baby assisted pregnancy,the AUC of this model for predicting failure of test-tube baby assisted pregnancy was 0.845,and its predictive efficacy was higher than that of each influencing factor alone(Z=6.832,5.905,6.832,6.258,all P＜0.05).Conclusion:Endometrial thicknes＜7 mm,endometrial morphology on HCG injection day was B or C,the duration of infertility＞3 years,embryo quality not good are risk factors for the failure of test-tube baby assisted pregnancy,the prediction model base on the above risk factors has a high predictive value for the pregnancy outcome of test-tube baby assisted pregnancy.
