Clinical Study of Aripiprazole Combined with Non-Convulsive Electroconvulsive Therapy for Children and Adolescents with First Episode Schizophrenia
10.13241/j.cnki.pmb.2025.12.013
- VernacularTitle:阿立哌唑联合无抽搐电休克治疗儿童青少年首发精神分裂症的临床研究
- Author:
Shao-dong RAN
1
;
Dao-yang LI
;
Ya-long LIU
;
Bin LI
;
Yi-rong CHEN
Author Information
1. 宜昌夷陵康宁精神病医院心理科 湖北宜昌 443100
- Publication Type:Journal Article
- Keywords:
Aripiprazole;
Non-convulsive electroshock;
Children;
Adolescents;
First episode schizophrenia
- From:
Progress in Modern Biomedicine
2025;25(12):2009-2016
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the clinical effect of aripiprazole combined with non-convulsive electroshock(MECT)for children and adolescents with first episode schizophrenia.Methods:94 children and adolescents with first episode schizophrenia who were admitted to Yiling Kangning Mental Hospital of Yichang from August 2022 to August 2024 were divided into control group(received aripiprazole,n=47)and study group(received aripiprazole combined with MECT,n=47)by using random number table method.The clinical efficacy,dysfunction scale[Positive and Negative Symptom Scale(PANSS),Montreal Cognitive Assessment Scale(MoCA),Wechsler Memory Scale(WMS)],glucose and lipid metabolism indexes[low density lipoprotein cholesterol(LDL-C),glycated hemoglobin(HbAlc),total cholesterol(TC),fasting blood glucose(FBG),High density lipoprotein cholesterol(HDL-C),inflammatory factor indexes[interleukin-1β(IL-1β),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)],neurocytokine levels[serum brain-derived neurotrophic factor(BDNF),s100βprotein(s100β),homocysteine(Hcy)]and the occurrence of adverse reactions were compared between the two groups.Results:Compared with the control group after treatment,the clinical total effective rate,MoCA,WMS score,HDL-C,BDNF were higher,PANSS score,HbAlc,FBG,TC,LDL-C,TNF-α,IL-1β,IL-6,s100β and Hcy were lower in the study group(P＜0.05).There was no difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion:Aripiprazole combined with MECT in the treatment of in children and adolescents with first episode schizophrenia can reduce the degree of inflammation,regulate glucose and lipid metabolism,improve clinical symptoms and neurological function of children,with good safety.
