Relationship between Serum sTM,sIL-2R and Short-Term Prognosis in Patients with Acute Exacerbation Chronic Obstructive Pulmonary Disease Combine with Type Ⅱ Respiratory Failure
10.13241/j.cnki.pmb.2025.11.017
- VernacularTitle:慢性阻塞性肺疾病急性加重期合并Ⅱ型呼吸衰竭患者血清sTM、sIL-2R与短期预后的关系研究
- Author:
Meng-fei YE
1
;
Xiao-lei WU
;
Xing-xia ZHANG
Author Information
1. 山东省立第三医院急诊科 山东济南 250031
- Publication Type:Journal Article
- Keywords:
Acute exacerbation chronic obstructive pulmonary disease;
Type Ⅱ respiratory failure;
Soluble thrombomodulin;
Soluble interleukin-2 receptor;
Prognosis
- From:
Progress in Modern Biomedicine
2025;25(11):1895-1904
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the relationship between serum soluble thrombomodulin(sTM),soluble interleukin-2 receptor(sIL-2R)and short-term prognosis in patients with acute exacerbation chronic obstructive pulmonary disease(AECOPD)combine with type Ⅱ respiratory failure(RF).Methods:251 patients with AECOPD combine with type Ⅱ RF who were admitted to our hospital from April 2021 to April 2024 were selected,the serum sTM and sIL-2R levels of all patients were detected,and the prognosis of 10 d after admission of patients was counted,patients were divided into death group(n=40)and survival group(n=211)according to different prognosis.Influencing factors were analyzed by multivariate logistic regression analysis,predictive value was analyzed by receiver operating characteristic(ROC)curve.Results:Serum sTM and sIL-2R levels in death group were higher than those in survival group(P＜0.05).long course of chronic obstructive pulmonary disease(COPD)and severe RF,high sTM and high sIL-2R were risk factors for death of 10 d after admission of patients with AECOPD combine with type Ⅱ RF(P＜0.05).The area under the curve(AUC)of serum sTM and sIL-2R detection in predicting death of 10 d after admission of patients with AECOPD combine with type Ⅱ RF was 0.801 and 0.810,respectively,the AUC of joint detection of serum sTM and sIL-2R was 0.859,which was higher than that of each index alone.Conclusion:Serum sTM and sIL-2R levels in patients with AECOPD combine with type Ⅱ RF are significantly increase,which are relate to the occurrence of poor prognosis of 10 d after admission,serum sTM and sIL-2R are expect to be used as auxiliary predictive markers for short-term prognosis of patients with AECOPD combine with type Ⅱ RF,and long course of COPD and severe RF,APACHE Ⅱ score are the influencing factors of poor prognosis in patients with AECOPD combine with type Ⅱ RF.
