Genotype and Influence Factors Analysis of HBV DNA Positive Samples of Negative HBsAg Donors in Blood Donors without Compensation in Nan'an Area
10.13241/j.cnki.pmb.2025.11.015
- VernacularTitle:南安地区HBsAg筛查阴性无偿献血者HBV DNA阳性标本的基因型及其影响因素分析
- Author:
Kai-qi CHEN
1
;
Yi-xiu SUN
;
Li-rong JIANG
Author Information
1. 南安市疾病预防控制中心微生物与临床检验科 福建南安 362300
- Publication Type:Journal Article
- Keywords:
Nan'an area;
HBsAg screening;
Negative;
Blood donors without compensation;
HBV DNA positive specimens;
Genotype;
Influencing factors
- From:
Progress in Modern Biomedicine
2025;25(11):1879-1885,1920
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study genotype analysis and influence factors analysis of hepatitis B virus(HBV)deoxyribonucleic acid(DNA)positive samples of negative hepatitis B surface antigen(HBsAg)donors in blood donors without compensation in Nan'an area.Methods:A total of 62,000 HBsAg fast-screened blood donor samples from January 2021 to June 2024 were selected as the study objects.HBV infection,viral load and genotype of HBV DNA positive samples,single factor and influencing factor of HBV DNA positive samples were detected and analyzed.Results:Among the 62000 HBsAg fast-screened blood donor samples,the results were negative by HBsAg screening,moreover,285 cases(0.46％)were HBsAg positive and 61715 cases(99.54％)were negative.NAT positive 180 cases and 118 cases were positive for HBV DNA.The HBV DNA positive rate of HBsAg negative donors was 0.19％(118/62000).HBV DNA of the viral load of positive specimens with＜20 IU/mL was higher than those with 20 to 99 IU/mL and ≥ 100 IU/mL(P＜0.05).HBV DNA of C style of the genotype of positive specimens was higher than B style and unsamples(P＜0.05).Univariate analysis found that HBV DNA positivity was mainly related to the history of intravenous drug use and risky sexual behavior,as well as the history of hepatitis B vaccination and blood transfusion(P＜0.05).According to the Logistic regression analysis,history of intravenous drug use and risky sexual behavior,and blood transfusion were risk factors for positive HBV DNA(OR＞1,P＜0.05),vaccination of hepatitis B vaccine was a protective factor for HBV DNA positivity(OR＜1,P＜0.05).Conclusion:The proportion of HBsAg in Nan'an area is relatively high,but there are still a small number of positive samples,the main genotype was type C,and history of intravenous drug use and risky risk behaviors,as well as history of blood transfusion were all risk factors for positive HBV DNA,vaccination of hepatitis B vaccine is protective factor for HBV DNA positivity.
