Evaluation Value of Blood Routine Derived Indicators Combined with Serum CRP and PCT Detection for Clinical Outcomes of Children with Mycoplasma Pneumoniae Pneumonia
10.13241/j.cnki.pmb.2025.12.017
- VernacularTitle:血常规衍生指标联合血清CRP、PCT检测对肺炎支原体肺炎患儿临床转归的评估价值
- Author:
Zhen-chang LIU
1
;
Yuan-fang LI
1
;
Juan LI
1
;
Qi CHEN
1
Author Information
1. 赣州市会昌县妇幼保健院检验科 江西赣州 342600
- Publication Type:Journal Article
- Keywords:
Derived neutrophil to lymphocyte ratio;
Red blood cell distribution width to platelet ratio;
C-reactive protein;
Procalcitonin;
Mycoplasma pneumoniae pneumonia;
Clinical outcomes
- From:
Progress in Modern Biomedicine
2025;25(12):2042-2047,2063
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the evaluation value of blood routine derived indicators[derived neutrophil to lymphocyte ratio(dNLR),red blood cell distribution width to platelet ratio(RPR)]combine with serum C-reactive protein(CRP)and procalcitonin(PCT)detection for the clinical outcomes of children with Mycoplasma pneumoniae pneumonia(MPP).Methods:149 children with MPP who were admitted to our hospital from April 2022 to August 2024 were included,they were divided into good prognosis and poor prognosis groups based on their clinical outcomes 28 d after admission.The blood routine derived indicators,serum CRP,and PCT levels between the good prognosis group and the poor prognosis group were compared.The influencing factors of clinical outcomes in children with MPP were analyzed by Multiple logistic regression analysis,the value of blood routine derived indicators,serum CRP,and PCT testing alone and in combination to evaluate the clinical outcomes of children with MPP were analyzed by receiver operating characteristic(ROC)curves.Results:Among 149 children with MPP,113 had good prognosis and 36 had poor prognosis 28 d after admission,with a poor prognosis incidence rate of 24.16％(36/149).dNLR,RPR,CRP,and PCT levels in the poor prognosis group were higher than those in the good prognosis group(P＜0.05).Univariate analysis showed that,the clinical outcome of children with MPP was related to pleural thickening,pleural effusion,severity disease and peak body temperature(P＜0.05).Multivariate Logistic regression analysis showed:Pleural thickening,pleural effusion,severity disease was severe,elevated dNLR,elevated RPR,elevated CRP and elevated PCT were risk factors for poor prognosis in children with MPP(P＜0.05).The area under the Curve(AUC)of dNLR,RPR,CRP and PCT combined to predict the prognosis of children with MPP was higher than that evaluated by the four indicators alone.Conclusion:Pleural thickening,pleural effusion,severe disease severity,elevated dNLR,elevated RPR,elevated CRP and elevated PCT are risk factors for poor prognosis in children with MPP.Moreover,the combined evaluate value of dNLR,RPR,CRP,and PCT is relatively high.
