A Randomized Controlled Study of Edaravone Dexborneol Combined with Aspirin and Clopidogrel in the Treatment of Acute Ischemic Stroke
10.13241/j.cnki.pmb.2025.12.014
- VernacularTitle:依达拉奉右莰醇联合阿司匹林、氯吡格雷治疗急性缺血性脑卒中的随机对照研究
- Author:
Ning CHAO
1
;
Dan-dan WANG
1
;
Lan MA
1
Author Information
1. 北京市房山区良乡医院神经内科 北京 102400
- Publication Type:Journal Article
- Keywords:
Edaravone Dexborneol;
Aspirin;
Clopidogrel;
Acute ischemic stroke;
Randomized controlled
- From:
Progress in Modern Biomedicine
2025;25(12):2017-2023
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the therapeutic effect of Edaravone Dexborneol combined with aspirin and clopidogrel in the treatment of acute ischemic stroke(AIS).Methods:82 AIS patients were randomly divided into control group(treated with aspirin and clopidogrel,n=41)and observation group(treated with Edaravone Dexborneol on the basis of control group,n=41)by random number table method.National Institutes of Health Stroke Scale(NIHSS),Montreal Cognitive Assessment Scale(MoCA),Barthel Index(BI),serum biochemical indicators[neuron specific enolase(NSE),superoxide dismutase(SOD),brain-derived neurotrophic factor(BDNF),malondialdehyde(MDA)],intracranial hemodynamic indicators[bilateral anterior cerebral artery(ACA),bilateral middle cerebral artery(MCA),bilateral posterior cerebral artery(PCA)],and incidence of adverse reactions during treatment were compared between the two groups.Results:The total clinical effective rate,MoCA,BI score,BDNF,SOD,and the average flow rates of ACA,MCA,and PCA in the observation group 14 d after treatment were higher than those in control group,NIHSS score,NSE,and MDA were lower than those in control group(P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion:Edaravone Dexborneol combined with aspirin and clopidogrel in AIS treatment can significantly improve intracranial hemodynamics,regulate nerve factors,reduce nerve function damage,and has good safety.
