Comparative analysis of CT findings in clear cell renal cell carcinoma with and without sarcomatoid
10.3969/j.issn.1002-1671.2025.04.017
- VernacularTitle:肾透明细胞癌伴与不伴肉瘤样变的CT表现对比分析
- Author:
Chuanxian MA
1
;
Chen CHEN
1
;
Yawen YANG
1
;
Shun CHAI
1
;
Zhanlong MA
1
Author Information
1. 南京医科大学第一附属医院放射科,江苏 南京 210029
- Publication Type:Journal Article
- Keywords:
sarcomatoid;
clear cell renal cell carcinoma;
computed tomography
- From:
Journal of Practical Radiology
2025;41(4):617-620
- CountryChina
- Language:Chinese
-
Abstract:
Objective To perform an analytical comparison of CT findings between sarcomatoid clear cell renal cell carcinoma(sccRCC)and grade 4 clear cell renal cell carcinoma(ccRCC),to improve preoperative diagnosis for sccRCC.Methods The pathology and imaging data of 18 patients with sccRCC and 23 patients with grade 4 ccRCC were retrospectively analyzed,the differences of non-contrast and contrast-enhanced CT features between the two groups were compared.Results(1)sccRCC and ccRCC demonstrated similar features regarding hemorrhage,calcification,retroperitoneal lymph node enlargement,distant metastasis,invasion of perinephric organs,vascular invasion,and neovascularization around and within the tumor,as well as CT values at different phases.No statistically significant differences were observed between the two groups(P＞0.05).(2)In the sccRCC,solid components were predominant in 6 cases,compared to 16 cases in the ccRCC,showed a significant difference(P=0.017).The ratio of cystic and necrotic areas in sccRCC was 0.66±0.20,and that in ccRCC was 0.51±0.17,with a statistically significant difference(P=0.015).(3)Using a cystic and necrotic area ratio of 0.63 as the diagnostic threshold yields the optimal discriminative performance,with an area under the curve(AUC)of 0.732,a sensitivity of 0.611,and a specificity of 0.826.Conclusion sccRCC is distinguished by a significantly higher proportion of cystic and necrotic elements as opposed to the grade 4 ccRCC.
