Research progress in the regulation of host immune metabolism by Mycobacterium tuberculosis
10.3969/j.issn.1002-2694.2025.00.054
- VernacularTitle:结核分枝杆菌调控宿主免疫代谢的研究进展
- Author:
Dan-dan ZHANG
1
;
Jia-xu WAN
;
Sha-sha FU
;
Cheng-kun ZHENG
;
Xiang CHEN
;
Zheng-zhong XU
;
Xin-an JIAO
Author Information
1. 江苏省人兽共患病重点实验室/江苏省动物重要疫病和人兽共患病防控协同创新中心,扬州大学,扬州 225009
- Publication Type:Journal Article
- Keywords:
tuberculosis;
Mycobacterium tuberculosis;
immune metabolism;
mitochondria
- From:
Chinese Journal of Zoonoses
2025;41(4):358-363
- CountryChina
- Language:Chinese
-
Abstract:
Immunometabolism studies focus on the relationships between immune cell functions and cellular energy metabolism pathways.Immunometabolism plays an important regulatory role in immune-related diseases.Mycobacterium tuberculosis(M.tb),an important intracellular pathogenic bacterium,enters alveolar macrophages after infection.The confrontation between M.tb and the host is a complex and dynamic process involving multiple aspects and mechanisms,such as the immune response,granuloma formation,and immune evasion.M.tb effector proteins play key roles in maintaining bacterial virulence and regulating host cell metabolism.This article reviews the reprogramming process of glucose metabolism,lipid metabolism,and immunometabolism,as well as changes in mi-tochondrial function in M.tb-infected host cells,thereby revealing the relationship between M.tb pathogenicity and host metabolic regu-lation,which is important for understanding tuberculosis.
