Research progress in anti-tuberculosis drug targets and novel therapeutic strategies
10.3969/j.issn.1002-2694.2025.00.058
- VernacularTitle:抗结核药物作用靶点及新型治疗策略的研究进展
- Author:
Yang ZHANG
1
;
Ming-rui SUN
1
;
Xiao-tian LI
1
;
Ren FANG
1
;
Jia-yin XING
1
;
Ning-ning SONG
1
Author Information
1. 山东第二医科大学生命科学与技术学院,潍坊市呼吸道病原菌及药物治疗重点实验室,潍坊 261053
- Publication Type:Journal Article
- Keywords:
anti-tuberculosis drugs;
Mycobacterium tuberculosis;
drug target;
tuberculosis treatment
- From:
Chinese Journal of Zoonoses
2025;41(4):351-357
- CountryChina
- Language:Chinese
-
Abstract:
Tuberculosis(TB),a chronic infectious disease caused by infection with the Mycobacterium tuberculosis complex(MTBC),has re-emerged as the leading cause of death from a single infectious agent worldwide.Because of widespread use and mis-use of anti-tuberculosis drugs,the emergence of multidrug-resistant TB(MDR-TB)and extensively drug-resistant TB(XDR-TB)is increasing,thus posing a serious threat to global health.The current problem of drug resistance is a major prevention and treatment challenge;therefore,the search for new drug targets is urgently needed.In recent years,substantial progress has been made in re-search on anti-tuberculosis drug targets and novel therapeutic strategies.Herein,we summarize recent research progress in anti-tuberculosis drug targets,primarily cell wall synthesis,nucleic acid replication and transcription,and energy metabolism.We also provide an overview of research progress regarding two novel therapeutic strategies,to provide a theoretical basis and research ideas for the development of new clinical drugs.
