Relationship between inflammatory factors and prognosis in elderly patients with critically ill tuberculosis
10.3969/j.issn.1002-2694.2025.00.061
- VernacularTitle:老年结核病危重症患者炎症因子与预后的关系
- Author:
Rui GUO
1
;
Chao-fan LI
;
Zhi CHEN
Author Information
1. 河北北方学院研究生院,张家口 075000;中国人民解放军总医院第八医学中心结核病医学部,北京 100091
- Publication Type:Journal Article
- Keywords:
elderly patients;
tuberculosis;
critical illness;
inflammatory factors;
prognosis
- From:
Chinese Journal of Zoonoses
2025;41(4):398-402
- CountryChina
- Language:Chinese
-
Abstract:
Older critically ill patients with tuberculosis may have multiple organ involvement and rapid disease progression,and often have high mortality.Consequently,high-risk patients must be identified early to receive aggressive treatment.The purpose of this study was to investigate the correlation between serum inflammatory factors and prognosis in older critically ill patients with tuberculo-sis,to provide a diagnosis and treatment basis for clinicians,and to facilitate early intervention for patients with poor prognosis.SPSS software was used to analyze data for 172 patients included in the study(82 patients in the survival group and 90 patients in the death group).Univariate analysis indicated significantly higher levels of IL-6,IL-1β,TNF-α,IL-8,IL-17,IL-12P70,IFN-γ,and IL-10 in the death group than the survival group(P<0.05).Multivariate logistic regression analysis demonstrated that IL-6(OR=1.002,95%CI:1.000-1.003,P=0.021),TNF-α(OR=1.175,95%CI:1.034-1.335,P=0.013),and IFN-γ(OR=1.008,95%CI:1.001-1.015,P=0.036)were independent risk factors,and the AUC of the three combined factors in predicting critical and severe tuberculo-sis prognosis in older patients was 0.771.Serum levels of IL-6,TNF-α,and IFN-γ were closely associated with the occurrence and development of tuberculosis in critically ill older patients.The combined detection of the three factors had a high clinical value for the assessment of prognosis of critically ill older patients with tuberculosis,and might be used to predict death in this patient group.
