Changes in brain activation patterns in different age groups in patients with chronic low back pain us-ing resting-state fMRI
10.3969/j.issn.1001-1242.2025.06.010
- VernacularTitle:不同年龄段慢性腰痛患者静息态脑激活模式变化的差异研究
- Author:
Shanshan ZHANG
1
;
Guifang ZHANG
;
Jianyang LAI
Author Information
1. 中山大学附属第一医院康复医学科,广州市,510080
- Publication Type:Journal Article
- Keywords:
chronic low back pain;
resting-state;
functional magnetic resonance imaging;
amplitude of low fre-quency fluctuation/ALFF;
age difference
- From:
Chinese Journal of Rehabilitation Medicine
2025;40(6):868-874
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore changes in brain activation patterns in different age groups of patients with chronic low back pain(cLBP)using resting-state functional magnetic resonance imaging(fMRI)and amplitude of low fre-quency fluctuation(ALFF).Method:Thirty-seven cLBP patients(age:20-30 years old,n=10;age:31-40 years old,n=13;age:41-55 years old,n=14)and twenty-four healthy subjects(12 male,12 female)were separately performed resting-state fMRI 3.0T scans.The fMRI data were analyzed with one-way ANOVA to compare ALFF changes of the brain activation patterns between different groups by DPARSF,REST and DPIBI software.Result:Patients with cLBP showed significantly ALFF difference in the bilateral frontal cortex,bilateral cere-bellum and left primary somatosensory cortex(FDR P<0.05).As the age cLBP patients increased,the ALFF in bilateral frontal cortex and left primary somatosensory cortex increased.In contrast,ALFF values in the cere-bellum increased in 20-30-year-old patients group,but decreased in 31-55-year-old patients group(P<0.05).Conclusion:The findings reveal abnormal spontaneous brain activity in different age groups of cLBP,indicat-ing that varied patient age or pain duration may induce different regulation patterns during persistent pain.
