Dietary supplementation of Lactiplantibacillus plantarum LP12 prevents obesity via regulating intestinal flora
10.16303/j.cnki.1005-4545.2025.03.28
- VernacularTitle:日粮中添加植物乳杆菌LP12通过调节肠道菌群预防肥胖
- Author:
Danni YE
1
;
Lingcong DENG
;
Xueyan AI
;
Yu DONG
;
Jiayu YU
;
Jiayi HAO
;
Mingyu LI
;
Wencong CHEN
;
Jiahao CHEN
;
Ziyi WANG
;
Jieying BAI
;
Maopeng WANG
Author Information
1. 温州大学病毒学研究所温州市病毒学和免疫学重点实验室,浙江温州 325005
- Publication Type:Journal Article
- Keywords:
Lactiplantibacillus plantarum;
obesity;
gut microbiota;
blood biochemistry;
antioxidant index;
microbiota function
- From:
Chinese Journal of Veterinary Science
2025;45(3):611-618
- CountryChina
- Language:Chinese
-
Abstract:
This study aims to investigate the effect of Lactiplantibacillus plantarum LP12 on obe-sity prevention.In our study,Lactiplantibacillus plantarum LP12 was added to the diet for feed-ing,and the blood biochemistry status of rabbit,as well as the antioxidant effect of serum and liver samples were analyzed by determining the body weight change and feed intake of Japanese White rabbits.The changes in colony structure and abundance were also analyzed by 16S rDNA sequen-cing.The results showed that supplementation of Lactiplantibacillus plantarum LP12 inhibits weight gain,decreases serum glucose and ALT levels,and increases SOD activity in the liver.16S RNA gene sequencing analysis showed that the addition of Lactiplantibacillus plantarum LP12 increases the abundance of Bacteroidetes and Desulfovibrioides at the phylum level,and the supple-mentation of Lactiplantibacillus plantarum LP12 increases the abundance of Muribaculaceae at the genus level.Predictive analysis of microbiota function revealed that the supplementation of Lactiplantibacillus plantarum LP12 positively regulated iron-sulfur clusters and Zn-dependent proteases.In conclusion,the addition of Lactiplantibacillus plantarum effectively inhibits weight gain in Japanese White rabbits,enhances the antioxidative activity of the liver,and induces altera-tions in the gut microbiota composition of these rabbits.These findings lay an experimental foun-dation for further exploring the mechanisms by which Lactobacillus plantarum LP12 exerts its preventive effects against obesity and promotes metabolic health.
