Study on lateralization of language related white matter fibers during post-stroke aphasia recovery period
10.3969/j.issn.1001-1242.2025.06.006
- VernacularTitle:卒中后失语恢复期语言相关脑白质纤维束的偏侧化研究
- Author:
Yuyuan WANG
1
;
Haozheng LI
1
;
Dongxiang FANG
1
Author Information
1. 复旦大学附属华山医院康复医学科,上海市,200040
- Publication Type:Journal Article
- Keywords:
post-stroke aphasia;
white matter fibers;
diffusion tensor imaging
- From:
Chinese Journal of Rehabilitation Medicine
2025;40(6):841-846
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the correlation between arcuate fasciculus(AF),superior longitudinal fasciculus(SLF),inferior longitudinal fasciculus(ILF),and post-stroke aphasia(PSA)by diffusion tensor imaging(DTI).Method:Fourteen patients with post-stroke aphasia were included,while 18 healthy individuals with gender and age matching were recruited as controls.Western aphasia battery(WAB)and DTI were performed in two groups of participants.Result:Compared with normal healthy controls,aphasic patients had dominant side AF,SLF-Ⅱ,SLF-Ⅲ,and ILF damage,with a significant decrease in fiber FA value,fiber quantity,and fiber length(P<0.05).However,dominant side SLF-I,non dominant side AF,SLF-I,SLF-Ⅱ,and SLF-Ⅲ had no significant damage(P>0.05).The non-dominant side ILF fiber quantity of non-dominant side in the aphasic group was significantly lower than that in the healthy control group(P<0.05).However,there were no significant decrease in the FA value and fiber length between two groups(P>0.05).There was no significant correlation between specific single bundle fi-ber damage and WAB's AQ,spontaneous speech,auditory comprehension,repetition and naming scores(P>0.05).Conclusion:The injury of AF,SLF-Ⅱ,SLF-Ⅲ,and ILF in the dominant side of the brain is an important central mechanism for the occurrence of PSA.
