Research progress on the regulation of PI3K/Akt signaling pathway by active ingredients of traditional Chinese medicine in the treat-ment of cerebral ischemia-reperfusion injury
10.12092/j.issn.1009-2501.2025.06.012
- VernacularTitle:中药有效成分调控PI3K/Akt信号通路治疗脑缺血再灌注损伤的研究进展
- Author:
Yidan ZHANG
1
;
Xinghua SUN
;
Yang QU
;
Xiaoyang HU
;
Miao ZHANG
Author Information
1. 黑龙江中医药大学基础医学院,哈尔滨 150040,黑龙江;黑龙江中医药大学附属第三医院,哈尔滨 150001,黑龙江
- Publication Type:Journal Article
- Keywords:
cerebral Ischemia-reperfusion injury;
traditional Chinese medicine;
active ingredient;
PI3K/Akt;
research progress
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2025;30(6):820-827
- CountryChina
- Language:Chinese
-
Abstract:
Cerebral ischemia-reperfusion injury can lead to secondary brain damage through com-plex pathological processes such as ion imbalance,inflammation,mitochondrial dysfunction,oxidative stress,and increased vascular permeability,serious-ly affecting the prognosis and quality of life of isch-emic stroke patients.How to effectively reduce and prevent neurological damage caused by CIRI has become a key and hot topic in CIS research.In re-cent years,many studies have confirmed that the active ingredients of traditional Chinese medicine can alleviate oxidative stress,inhibit autophagy,regulate cell apoptosis,control neuroinflammation,reduce cell apoptosis index,alleviate neuronal his-topathological damage,promote neuronal survival,enhance synaptic plasticity,and play a therapeutic role in CIRI through the PI3K/Akt signaling pathway.In summary,this article provides a review of the PI3K/Akt signaling pathway and its role in CIRI,as well as the research on the regulation of PI3K/Akt signaling by active ingredients in traditional Chi-nese medicine for the treatment of CIRI.The aim is to provide a theoretical basis for the clinical use of active ingredients in traditional Chinese medicine to alleviate CIRI damage.
